Design, Implementation, Monitoring, and Sharing of Performance Standards for Laboratory Animal Use Summary of a Workshop (2015) / Chapter Skim
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7 Sharing Acceptable Performance Standards
7 Sharing Acceptable Performance Standards
Pages 81-90
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From page 81... ...
Together, these numbers translate into fewer investigators getting funded (Figure 7Ͳ2)
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From page 82... ...
82 SHARING ACCEPTABLE PE ERFORMANCE S STANDARDS FIGU 7Ͳ1 Expend URE ditures on reseearch and deve elopment by th he pharrmaceutical ind dustry in real and 1995 const a tant dollars SOUURCE: Niemi slid 5 de FIGU 7Ͳ2 Succes rates, by car URE ss reer stage of in nvestigator, for securing NIH r ROͲ1 equivalent gr 1 rants SOUURCE: Niemi slid 7 de
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From page 83... ...
Up to 30 percent of that, he calculated, is unnecessarily spent trying to meet engineering standards, so a conservative estimate of 20 percent waste would translate into $86 million dollars that could be spent funding 48 additional averageͲsize awards. Even more distressing, said Niemi, are the generational changes underway.
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From page 84... ...
Age 66 and O nd . Older, Fiscal Yeaar 1990 – 2014 0 SOUURCE: Niemi slid 9 de FIGU 7Ͳ4 The graying of acade URE emic science fro 1980 to 20 om 013 SOUURCE: Niemi slid 10 de
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From page 85... ...
, including head cover, face mask, gloves, Tyvek jumpsuit, and shoe covers. Given that Harvard's animal facilities use ventilated cages, laminar flow, purified air, and hoods for animal work, Niemi copied procedures established at the University of Michigan and the University of Houston that require only personnel working with rodents or handling animalͲcontaminated products to wear gloves and a paper gown.
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From page 86... ...
Niemi explained his facility had piloted spot changing immediately prior to an AAALAC site visit, but the study was not completed before the AAALAC review. He noted current standard practice at most institutions is to spot change before two weeks based on decisions made by animal care technicians, but he does not believe this policy is based on rigorous scientific criteria.
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From page 87... ...
x Eliminate annual reviews of nonͲUSDA, nonͲDepartment of Defense research protocols. Turning to the assigned topic of his talk – how to share and promote performance standards – Niemi first discussed his thoughts on the process to enable the dissemination of a performance standard, which should be based on standards that are evidenceͲbased, accompanied by many examples of local adoption deposited in one or more public repositories and have been approved by an IACUC.
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From page 88... ...
Niemi replied that his preference would be to seek support from other sources first. Clarke and Jarrell seconded Niemi's suggestion of the roundtable driving the creation of a repository, and Clarke hoped the repository would contain examples of performance standards that did not work.
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From page 89... ...
Jarrell reemphasized the importance of talking with the people who are directly working with the animals and asking them where they see opportunities for improvement, including reallocating time to activities that benefit the welfare of the animals. Her staff, for example, did not like disturbing animals in clean cages and were excited to participate in the spot cleaning study.
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