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Veterans and Agent Orange Update 2014 (2016) / Chapter Skim
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5 Epidemiologic Studies: Compendium of New Publications
Pages 133-144

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From page 133...
... In this chapter and later chapters, epidemiologic studies are organized into categories according to the populations being studied (Vietnam veterans, occupational populations other than Vietnam veterans, and nonoccupational populations affected by environmental exposures) or by study design (case-control)
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From page 134...
... (Design information on the studies of new populations that involve single health outcomes is provided in the various health-outcomes chapters.) In addition to reviewing studies involving exposures to the specific COIs listed previously, this and earlier VAO committees have considered studies that examined compounds chemically related to the herbicides used in Vietnam, such as 2-(2-methyl-4-chlorophenoxy)
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From page 135...
... Author Design Results Reported Study Population Studies of Vietnam Veterans Ansbaugh Cohort "Agent Orange" as Prostate cancer 2,720 veterans et al., 2013 per US Department referred to the of Veterans Affairs Portland Veterans designation Affairs Medical Center Li Q et al., Cohort Dioxin-TEQ Prostate cancer, 93 Vietnam 2013 levels measured biochemical veterans who in abdominal recurrence underwent radical subcutaneous fat after radical prostatectomy, prostatectomy median of 5.3 yrs of post-operative follow-up Environmental Studies Delvaux Cohort EDCs, including Prenatal exposure Flemish children; et al., 2014 dioxin (TEQs) and to EDCs and body part of the Flemish non-dl PCBs in composition at 7–9 Environment and cord blood years of age Health Study Ferguson Cohort POPs in serum Reproductive Male partners et al., 2012 (including dl-PCBs hormones (aged 18–51)
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From page 136...
... Author Design Results Reported Study Population Kim et al., Cross- PCB congeners Free t3, total T3, 138 pregnant 2013 sectional free T4, total T4, women from 5 TSH Korean hospitals Medehouenou Cohort OC pesticides and Dementia Canadian Study of et al., 2014 PCBs measured in Health and Aging, plasma, including a national cohort dl-PCBs 105, 118, study of Canadians and 156 65+ years of age Nakamoto Cross- PCDD/Fs, dl- History of disease, Japanese men et al., 2013 sectional PCBs, and total including asthma, (1,063) and women dioxins in blood atopic dermatitis, (1,021)
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From page 137...
... Publications Reporting Multiple Health Outcomes in New Populations The new publications reporting multiple health outcomes in populations not studied previously are listed in Table 5-2 with a list of outcomes that were investigated. Comprehensive discussions of the designs of the studies are presented in Chapter 6, organized according to the type of study population.
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From page 138...
... Author Design Results Reported Study Population Studies of Vietnam Veterans McBride et al., Cohort Service in Vietnam Mortality and New Zealand 2013 during Vietnam War cancer experience Vietnam war (1988–2008) veterans Yi, 2013 Cohort Service in Vietnam Cancer incidence KVHS–Korean during the Vietnam 1992–2003; Vietnam veterans War all cancers and identified using full spectrum the Korea National individually Cancer Incidence Database Yi and Ohrr, Cohort AO exposure using Cancer incidence KVHS–Korean 2014 GIS-based model 1992–2003; Vietnam veterans all cancers and identified using full spectrum the Korea National individually Cancer Incidence Database Yi et al., 2014a Cohort AO exposure using Disease prevelance, KVHS–Korean GIS-based model full spectrum Vietnam veterans individually identified using Korean National Health Insurance Health claim data, January 2000– September 2005 Yi et al., 2014b Cohort AO exposure using Morbidity and KVHS–Korean GIS-based model mortality from Vietnam veterans individual cancers with cause of death and various diseases reported 1992–2005 Occupational Studies Wang et al., Cohort PCDDs/PCDFs Lung, liver, and Workers from an 2013 stomach cancer, automobile foundry individually factory in Hubei province in China Environmental Studies Papadopoulou Cohort Dietary intake Maternal diet and Mothers enrolled in et al., 2013a of dioxins and birth size Norwegian Mother dl-compounds and Child Cohort Study
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From page 139...
... Author Design Results Reported Study Population Papadopoulou Cohort dl activity in Anogenital distance Mothers and et al., 2013b maternal blood in newborns and newborns enrolled samples at time children in European of delivery and NewGeneris Cohort anogenital distance in newborns and infants Papadopoulou Cohort dl activity in Association Mothers enrolled et al., 2014 maternal blood between maternal in European samples at time of diet and birth NewGeneris Cohort delivery outcome Vafeiadi et al., Cohort In utero exposure In utero exposure Subset of mother– 2013 to dioxin and to dioxin and Child cohorts from dl-compounds dl-compounds and NewGeneris Cohort anogenital distance Vafeiadi et al., Cohort dl activity in cord dl activity in blood Mothers and 2014 blood and maternal and birth weight, newborns enrolled blood samples at gestational age, and in European time of delivery head circumference, NewGeneris Cohort NOTE: AO, Agent Orange; dl, dioxin-like; GIS, geographic information system; KVHS, Korean Veterans Health Study; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran. comments related to their reliability or limitations, appear in the appropriate outcome-specific sections of Chapters 7–13.
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From page 140...
... Study Author Study Design Having Results Reported Population Studies of Vietnam Veterans Kang et al., Retrospective US military Mortality 1965– US women 2014 cohort service in 2010; all cancers who served Vietnam or near and specific (brain, in Vietnam or Vietnam breast, cervical, near-Vietnam ovarian, pancreatic, vs non-Vietnam respiratory, uterine) , veteran peers in diabetes mellitus, the US heart disease, circulatory disease, respiratory disease, and nervous system disease ADVA, 2014a,b Cohort Vietnam veteran Study overview, Vietnam veteran families pregnancy and birth sons and defect outcomes daughters ADVA, 2014c Cohort Vietnam veteran Mortality patterns Vietnam veteran families families Occupational Studies Goldner et al., Cohort 50 specific Association between AHS (male 2013 herbicides, thyroid disease and private pesticide including 2,4-D, use of insecticides, applicators)
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From page 141...
... Study Author Study Design Having Results Reported Population Environmental Studies Bouchard et al., Cross- PCB congeners Cognitive function NHANES 2014 sectional (1999–2002) Chevrier et al., Cohort Serum TCDD Thyroid hormone SWHS (Seveso 2014 concentrations levels women 0–40 yrs old at time of accident; follow-up April 2008–December 2009)
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From page 142...
... Study Author Study Design Having Results Reported Population ten Tusscher Cohort Pre-, peri-, Neurodevelopmental Amsterdam– et al., 2014 and postnatal retardation Zaandam cohort; (same cohort as exposure to children born Patandin et al., dioxin 1987–1991 1998) Turunen et al., Cohort PCDDs, PCDFs, C-reactive protein Finnish 2012 PCBs (an indicator of fisherman and inflammation)
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From page 143...
... Study Author Study Design Having Results Reported Population Yang et al., 2014 Case-control 2,4-D Neural tube defects NBDPS and orofacial clefts NOTE: 2,4-D, 2,4-dichlorophenoxyacetic acid; 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; 2,4,5-TP, 2-(2,4,5-trichlorophenoxy) propionic acid; AHS, Agricultural Health Study; CCSPH, Cross-Canada Study of Pesticides and Health; CVD, cardiovascular disease; dl, dioxin-like; IARC, International Agency for Research on Cancer; MCPA, 2-methyl-4-chlorophenoxyacetic acid; NBDPS, National Birth Defects Prevention Study; NHANES, National Health and Nutrition Examination Survey; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; PIVUS, Prospective Study of the Vasculature in Uppsala Seniors; POP, persistent organic pollutant; SWHS, Seveso Women's Health Study; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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From page 144...
... The subjects of the new epidemiological studies identified include female US Vietnam veterans as well as Australian, Korean, and New Zealand veterans who served in Vietnam. These studies are augmented with a wealth of new data from civilian populations exposed to the COIs along with herbicides and pesticides with mechanistic and toxic properties similar to the COIs.
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Key Terms

  • results reported
  • epidemiologic studies
  • study population
  • publications reporting
  • study design

  • multiple health
  • design results
  • serum tcdd
  • health study
  • study author

  • vietnam veteran
  • single health
  • health outcome
  • vao committees
  • studied previously

  • study populations
  • vietnam war
  • studied populations
  • reporting multiple
  • design information

  • population studies
  • environmental studies
  • exposure using
  • previously studied
  • pcb congeners

  • sectional pcbs
  • saberi hosnijeh
  • cancer incidence
  • cohort service
  • study participants


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