Chemical Laboratory Safety and Security A Guide to Developing Standard Operating Procedures (2016) / Chapter Skim
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5 APPLICATION OF THE *GUIDE TO DEVELOPING STANDARD OPERATING PROCEDURES*
5 APPLICATION OF THE *GUIDE TO DEVELOPING STANDARD OPERATING PROCEDURES*
Pages 37-68
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From page 39... ...
The following four hypothetical scenarios demonstrate how to use the tools described in this Guide to Developing Standard Operating Procedures. The entries in the four forms were completed by the expert committee and are solely for illustrative purposes; real situations will call for procedures that are suited to the specific laboratory surroundings and personnel.
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From page 40... ...
To obtain the product, the medium is neutralized with concentrated hydrochloric acid. The use of concentrated acid helps keep the total reaction fluid volume low, thereby optimizing precipitation or extraction of the product.
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From page 41... ...
Inclusion and exclusion scope criteria Management and Process risk mitigation Type of SOP X storage Assessment of Assessment of X chemical and process X risk type vis Storage Matrix conditions High Risks Moderate Risks Low Risks Storage SOP High Risk SOP Moderate Risk: Neutralizing Moderate Risk SOP carbonate with acid causes evolution of CO2 Laboratory standards are sufficient [ 41 ]
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From page 42... ...
Personal protective equipment Lab coat, long pants, closed-toed shoes, double gloves (vinyl gloves over nitrile gloves) , safety goggles Engineering and environmental Any handling of concentrated hydrochloric acid outside of the fume controls hood is limited and done within closed containers only.
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01/29/2017 9. LIST OF REFERENCES (include Safety Data Sheets, Globally Harmonized System, any out side personnel consulted in the preparation of the document, peer reviewers, etc.)
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If yes, then list and describe modifications Were modifications made to current SOP? Yes ¨ No ¨ If no, then list date of approval Last reviewed by (please print)
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From page 45... ...
After reviewing section 9.7.4 of the National Academies of Sciences, Engineering, and Medicine report, A Guide to Prudent Chemical Management, the researcher discovers special hazards that may be encountered when filtering the hydrogen-saturated catalyst from the flammable organic reactants. Suggested solution: To minimize fires and explosions during the filtration step, the researcher goes through a hazard assessment checklist.
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From page 46... ...
Inclusion and exclusion scope criteria Management and Process risk mitigation Type of SOP X storage Assessment of Assessment of X chemical and process risk type vis Storage Matrix conditions High Risks X Moderate Risks Low Risks Storage SOP High Risk SOP High Risk: Manipulation of pyrophoric catalyst in presence of flammable solvent Moderate Risk SOP Laboratory standards are sufficient [ 46 ]
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From page 47... ...
maintaining an inert gas purge or blanket above the pyrophoric catalyst, and (3) eliminating clutter and any additional fuel sources from the immediate work area.
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From page 48... ...
Engineering controls: The following operations are conducted in a functioning fume hood with sash. PPE requirements: Flame-resistant lab coat, face shield, gloves appropriate for the solvent being used (consult a glove selection guide)
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From page 49... ...
are conducted in a fume hood with sash. PPE requirements: Flame-resistant lab coat, face shield, gloves appropriate for the solvent being used (consult a glove selection guide)
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From page 50... ...
2.10 After purging the waste container with inert gas, properly Label the waste jar properly, and use cap and label the container. appropriate warning signs.
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Personal Protective Equipment Check box if applicable Description Gloves þ Appropriate for solvent being used. (consult a glove selection guide)
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Immediately place the used paper towels in the waste container designated for pyrophoric catalysts -- do not allow the contaminated towels to dry in the air. Purge the waste container with inert gas and then cap tightly.
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From page 53... ...
is suggested that waste containers containing pyrophoric catalysts contain ample water to ensure the It solids remain wetted. The container will be flushed with inert gas and then tightly capped.
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02/10/2017 17. LIST OF REFERENCES (include Safety Data Sheets, Globally Harmonized System, any out side personnel consulted in preparation of document, peer reviewers, etc.)
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If yes, then list and describe modifications Were modifications made to current SOP? Yes ¨ No ¨ If no, then list date of approval Last reviewed by (please print)
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From page 56... ...
because it is less likely to explode as it generates diazomethane in situ and may be used for the reaction. TMSD is commercially available in anhydrous hexanes or diethyl ether, and the respective Safety Data Sheets are available online.
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From page 57... ...
Inclusion and exclusion scope criteria Management and Process risk mitigation Type of SOP X storage Assessment of Assessment of X chemical and process risk type vis Storage Matrix conditions High Risks X Moderate Risks Low Risks Storage SOP High Risk SOP High Risk: Diazomethane is extremely toxic when inhaled Moderate Risk SOP Laboratory standards are sufficient [ 57 ]
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From page 58... ...
333-4444 5. IDENTIFY ANY TRAINING NEEDS: No specific training required Experimental techniques Specific training required Users requiring training Date completed 6.
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From page 59... ...
PPE: exam-grade nitrile gloves are sufficient. 2.1 Add excess acetic acid until any yellow color Diazomethane is yellow, and reaction completion dissipates and gas evolution ceases.
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From page 60... ...
Personal Protective Equipment Check box if applicable Description Gloves þ Nitrile 8-mil gloves recommended. If contact is likely, then double glove using a second exam-grade nitrile glove first and the utility-grade nitrile glove second.
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From page 61... ...
The collection of vapors by an adsorption tube containing a resin coated with octanoic acid, followed by desorption with carbon disulfide can be measured by gas chromatographic analysis. Leak checking Gas and spill release monitoring Temperature and pressure Alarms [ 61 ]
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From page 62... ...
Process shutdown If spill happens inside fume hood, then immediately close sash and let evaporate. Activate emergency exhaust.
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From page 63... ...
01/15/2017 17. LIST OF REFERENCES (include Safety Data Sheets, Globally Harmonized System, any out side personnel consulted in preparation of document, peer reviewers, etc.)
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If yes, then list and describe modifications Were modifications made to current SOP? Yes ¨ No ¨ If no, then list date of approval Last reviewed by (please print)
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From page 65... ...
When the student picks up the chemical reagent, the laboratory manager provides a copy of the Safety Data Sheet, notes the hazardous nature of the chemical, and recommends that the student speak with his or her professor before running the first reaction to discuss safe handling for the reaction. In that discussion, the student and professor agree that a Moderate Risk SOP should be drafted for the use of this reagent.
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From page 66... ...
The laboratory manager searches the existing chemical inventory and finds a recently ordered bottle (2 M dissolved in diethyl ether) in one of the laboratory refrigerators.
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From page 67... ...
Inclusion and exclusion scope criteria Management and X Process risk mitigation Type of SOP storage Assessment of Assessment of chemical and process risk type vis Storage conditions Matrix High Risks Moderate Risks Low Risks Storage SOP High Risk SOP Moderate Risk SOP Laboratory standards are sufficient [ 67 ]
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From page 68... ...
CHEMICAL STORAGE MATRIX CONSIDERATIONS Aggregated Segregated Secured Ventilated Storage at Sodium Azide Piperonal Room Temperature Flammable Storage/ STORAGE OPTIONS Non-Ventilated at Room Temperature Open Laboratory Shelving (Trimethylsilyl) Low Temperature Diazomethane Compressed Gas Storage [ 68 ]
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