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Clinical Applications of Mifepristone (RU486) and Other Antiprogestins Assessing the Science and Recommending a Research Agenda (1993) / Chapter Skim
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Antiglucocorticoid Effects of Antiprogestins
Pages 52-56

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 52...
... Present knowledge is insufficient to set a rational strategy that would assure the synthesis of such pharmaceutical agents; therefore, the search now proceeds using empirical tactics and the outcome of this research is, as always in research, unpredictable. GLUCOCORTICOID FUNCTION Glucocorticoids are steroid hooves produced by the adrenal glands in response to stimulation by the pituitary hormone adrenocorticotropin (ACTH)
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From page 53...
... Cushing's syndrome is a generic term describing chronic excess glucocorticoid production that may be secondary to ACTH secretion by a tissue other than the pituitary (ectopic secretion) , or elevated ACTH due to a defective feedback mechanism in which the homeostatic regulatory mechanism does not function correctly (changed "set pointy.
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From page 54...
... Studies in rabbits have demonstrated that local application of eye drops containing mifepristone can lower intraocular pressure (Philips et al., 1984~. Moreover, it is unlikely that enough mifepristone would be administered by this route to increase adrenal cortisol secretion.
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From page 55...
... Therefore, the committee recommends expanded efforts to produce pure antiprogestins that would not display any other endocrine effects at therapeutic doses. REFERENCES Bakker, G.H., Setyono-Han, B., Portengen, H., et al.
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From page 56...
... Klijn, J.G.M., de Jong, F.H., Bakker, G.H., et al. Antiprogestins, a new form of endocrine therapy for human breast cancer.
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Key Terms

  • cortisol secretion
  • pure antiprogestins
  • endocrine effects
  • negative feedback
  • ectopic secretion

  • muscle atrophy
  • clinical applications
  • defective feedback
  • feedback mechanism
  • acth secretion

  • adrenal insufficiency
  • excess glucocorticoid
  • pure antiglucocorticoids
  • adverse antiglucocorticoid
  • glucocorticoid antagonist

  • steroid hormones
  • chemists trying
  • existing antiprogestins
  • therapeutic doses
  • selective inhibition

  • prototype glucocorticoid
  • influence glucocorticoid
  • medical reasons
  • homeostatic regulatory
  • regulatory mechanism

  • intraocular pressure
  • eye drops
  • antagonistic effects
  • relative adrenal
  • usually inversely


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