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Gene Drives on the Horizon Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016) / Chapter Skim
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9 Gene Drives on the Horizon: Overarching Considerations
Pages 177-179

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From page 177...
... Recommendation 9-1: Funders of gene drive research should coordinate, and if feasible collaborate, to reduce gaps in knowledge not only about the molecular biology of gene drives, but also in other areas of fundamental and applied research that will be crucial to the responsible development and application of gene drive technology, including popula tion genetics, evolutionary biology, ecosystem dynamics, modeling, ecological risk as sessment, and public engagement. Recommendation 9-2: Funders of gene drive research should establish open access, online repositories of data on gene drives as well as standard operating procedures for gene drive research to share knowledge, improve frameworks for ecological risk assessment, and guide research design and monitoring standards around the world.
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From page 178...
... Ongoing and iterative public engagement can help to frame and define the relevant harms and benefits of gene-drive modified organisms, provide input into risk assessment and practical decision making, and align research and policy with public values. It will be particularly important for ecological risk assessment to reflect the values of relevant publics, and for the assessments to inform public policy decisions about emerging gene drive technologies, including comparisons with alternative strategies.
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From page 179...
... Risk assessment, public engagement, and regulatory approval contribute to proof of acceptability. The cost-effectiveness of the technology versus alternative technologies may influence both acceptability and deliverability.
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Key Terms

  • gene drives
  • modified organisms
  • drive research
  • ecological risk
  • public engagement

  • field trials
  • genome editing
  • significant benefits
  • genetic elements
  • standard operating

  • government accountability
  • modified organism
  • assess environmental
  • editing tool
  • controlled field

  • justify proceeding
  • approval contribute
  • distinguishing characteristics
  • guidelines established
  • inform public

  • meaningful input
  • field research
  • able gaps
  • proposed applications
  • inform communities

  • alternative strategies
  • robust ecological
  • environmental releases
  • work remains
  • insufficient evidence


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