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Gene Drives on the Horizon Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016) / Chapter Skim
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Glossary
Pages 180-186

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 180...
... Asilomar: The 1975 Asilomar Conference on Recombinant DNA, convened to discuss the potential biohazards of recombinant DNA research, guidelines on safe laboratory practices, and the potential roles of regulation. The conference concluded that containment be made an essential aspect of experimental design, and that the effectiveness of containment practices matches the estimated risk of the particular experiment as closely as possible.
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From page 181...
... CRISPR/Cas9: A gene editing platform in which an endonuclease and a guide RNA are used to introduce double strand breaks at a specified location within the genome. Dual use potential: The potential for the findings from research intended for human benefit to be misused for intentionally harmful purposes.
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From page 182...
... Gene editing: A technique that allows researchers to alter the DNA of organisms to insert, delete, or modify a gene or gene sequences to silence, enhance, or otherwise change an organism's specific genetic characteristics. Gene flow: The transfer of genetic information from one population into another population (also called gene migration)
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From page 183...
... Also called native species. Institutional Animal Care and Use Committee: A multidisciplinary committee responsible for providing ethical review and oversight of research involving animal subjects, with the goals of protecting animal welfare and ensuring the quality of the science (also called an animal welfare committee)
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From page 184...
... Recombinant DNA (rDNA) : Any novel DNA sequence created using genetic engineering.
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From page 185...
... : A natural mechanisms found in nearly all organisms in which the levels of transcripts are reduced or suppressed. Scientific community: A dynamic international, multidisciplinary network of scientists and scientific institutions including, for example, investigators, science educators, universities, research institutes, funding organizations, regulatory bodies, and publishers, united by their common commitment to the advancement of scientific knowledge through the use of critical, reproducible methods.
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From page 186...
... Zinc finger nucleases: A class of engineered restriction enzymes generated by the fusion of a zinc finger DNA-binding domain to a DNA-cleavage domain that can be used as a genome editing tool.
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Key Terms

  • genetic engineering
  • monte carlo
  • recombinant dna
  • dna sequence
  • safe handling

  • enzymes generated
  • restriction enzymes
  • release site
  • laboratory practices
  • providing ethical

  • safe laboratory
  • zinc finger
  • animal welfare
  • research involving
  • ethical review

  • double strand
  • engineered restriction
  • prevent unintended
  • multidisciplinary committee
  • ethics committee

  • final probability
  • dna research
  • human benefit
  • infectious agents
  • international agreement

  • living organisms
  • science educators
  • agricultural crops
  • environmental controls
  • professional standards


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