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Gene Drives on the Horizon Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016) / Chapter Skim
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Appendix D Rodent Control Strategies
Pages 197-200

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From page 197...
... Genetic Engineering Strategies in Development One method being explored takes advantage of the process of RNA interference (RNAi) , in which double-stranded RNAs that target endogenous RNAs essential for the life of the rodent would be introduced to the rodent in an analogous fashion to that observed currently for agricultural pests (Xue et al., 2012)
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From page 198...
... Species elimination Little to no risk to human Inability to discriminate between target Lorvelec and Pascal, 2005; or translocation health or environment, no and non-target species Witmer and Jojola, 2006 toxins released to ecosystem Animal welfare issues Hygnstrom and Virchow, 1992 Biological controls Species elimination Easy to identify, potential Biological controls Garden, 2005; decreased risk to humans Saunders et al., 2010; Weber, 2010 Sometimes species-specific in their efficacy No action (i.e., species remains N/A No cost Damage to biodiversity; other (ecological outcomes) in the environment)
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From page 199...
... , and the need to ensure that infected rodents mate with one another as opposed to untreated rodents. Another line of research involves a genetic approach in which rodents could carry transgenes that, upon mating to the invasive population, do not produce any progeny (e.g., lethality)
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From page 200...
... 2012. New approaches to agricultural insect pest control based on RNA interference.
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Key Terms

  • species elimination
  • biological controls
  • animal welfare
  • rna interference
  • multiple releases

  • require multiple
  • tural pests
  • mechanical methods
  • feedings required
  • observed currently

  • painful death
  • research involves
  • biotechnology australia
  • innovative technologies
  • technique include

  • genetic factors
  • multiple doses
  • control based
  • population reduction
  • using immunocontraception

  • sex reversal
  • control agricultural
  • occasional paper
  • rnas essential
  • transgenic approaches

  • fertility control
  • techniques developed
  • vertebrate pest
  • biosafety risks
  • welfare issue


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