Exploring the State of the Science in the Field of Regenerative Medicine Challenges of and Opportunities for Cellular Therapies: Proceedings of a Workshop (2017) / Chapter Skim
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Appendix B: Speaker Biographical Sketches
Appendix B: Speaker Biographical Sketches
Pages 95-106
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From page 95... ...
He has been a grant reviewer for the National Cancer Institute, given numerous invited seminars and has served on several national scientific boards (International Consortium for Innovation and Quality in Pharmaceutical Development, International Serious Adverse Event Consortium)
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From page 96... ...
. His achievements include the launch of the London Project to Cure Blindness, which aims to develop a stem cell therapy for the majority of all types of age-related macular degeneration; seminal work on retinal transplantation; and the development of a cell-based therapy for a currently untreatable form of macular degeneration, age-related macular degeneration (also called dry AMD)
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From page 97... ...
Important contributions from the Daley laboratory include the creation of customized stem cells to treat a genetic immune deficiency in mice, the differentiation of germ cells from embryonic stem cells, the generation of disease-specific pluripotent stem cells by direct reprogramming of human skin and blood cells, and demonstration of the role of the LIN28/let7 signaling pathway in the development of cancer. Previously, Dr.
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From page 98... ...
She obtained a master of public health degree from East Carolina University and is presently working as a consultant with the Sickle Cell Treatment Demonstration Program at Sickle Cell Disease Foundation California and the Sickle Cell Disease Newborn Screening Program at the Sickle Cell Disease Association of America in Baltimore, Maryland.
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From page 99... ...
Her research focuses on the repair and regeneration of the lungs and how the normal repair mechanisms go awry in lung diseases. Her lab is using novel human three-dimensional models to understand repair and regeneration in the proximal and distal lung and has expertise in adult stem cell models of lung diseases and patient-specific induced pluripotent stem cell lung disease modeling and high-throughput drug screening.
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From page 100... ...
Laboratory research is focused on achieving efficient genetic correction of patient hematopoietic stem cells. Related work includes studies of the generation of induced pluripotent stem cells from patients with CGD and XSCID and the use of gene targeting methods to genetically correct induced pluripotent stem cells or hematopoietic stem cells.
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From page 101... ...
, the Research Achievement Award of the International Society for Heart Research, the Gill Heart Institute Award, and the distinguished scientist awards of the AHA and the American College of Cardiology. Anthony Oro, M.D., Ph.D., is a professor of dermatology, associate director of the Center for Definitive and Curative Medicine, a member of the Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Cancer Institute at Stanford University, and the Cancer Biology and Stem Cell graduate student programs.
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From page 102... ...
Oro has extended the original studies focusing on the role of skin stem cells to understand in tissue regeneration and carcinogenesis. He has a long-standing interest in the mechanisms of hedgehog signaling in hair follicle regeneration, and in the pathogenesis of the most common human tumor, basal cell carcinoma of the skin.
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From page 103... ...
In 2002 his group was the first to report the design of "second-generation" CARs that, in addition to a binding domain outside of the T cell and a signaling domain inside, included a costimulatory domain designed to promote cell proliferation and survival. These advances provided a broad platform to enhance CAR T cell therapy, leading directly to the development of new CAR T cell therapies that are showing increasing efficacy in patients.
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From page 104... ...
In his laboratory, he has established techniques that can turn human pluripotent stem cells into many of the diverse cell types of the nervous system. He was also among the first to realize the potential of patient-specific stem cell in modeling human disease and in drug discovery.
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From page 105... ...
In recognition of her work, Dr. Temple has received the Royal Society Stothert Research Fellowship, the Javits National Institutes of Health merit award, the MacArthur award and the Ellison investigator award.
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From page 106... ...
Urnov led the company's research and development efforts to deploy genome editing for crop trait engineering in partnership with Dow AgroSciences, and he co-managed Sangamo's partnership with Sigma-Aldrich for the generation of engineered cell lines for manufacturing, transgenic animals, and research reagents. He is an author of more than 70 scientific publications and an inventor on more than 100 issued and pending U.S.
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