Skip to main content

Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals (2017) / Chapter Skim
Currently Skimming:

Appendix B: Workshop on Potential Case Studies for Unraveling Endocrine-Related Low-Dose Toxicity
Pages 166-171

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 166...
... 1:30 Case Example 3: Bisphenol A and Female Reproductive Effects Moderators: Weihsueh Chiu, Katrina Waters, Karen Robinson Panelists:  Joseph Braun, Brown University  Daniel Doerge, U.S. Food and Drug Administration  Jodi Flaws, University of Illinois at Urbana-Champaign (via teleconference)
Read the entire page →
From page 167...
... Secondary outcomes: Indicators of male reproductive effects, including altered levels of endocrine or biochemical signaling molecules (fetal testosterone, fetal testis steroidogenic or cholesterologenic proteins, and insulin-like factor 3) , receptors, or mRNAs; and changes in cell proliferation.
Read the entire page →
From page 168...
... ; and changes in anogenital distance. Secondary outcomes: Indicators of male reproductive effects, including altered levels of endocrine or biochemical signaling molecules (fetal testosterone, fetal testis steroidogenic or cholesterologenic proteins, and insulin-like factor 3)
Read the entire page →
From page 169...
... Male nonhuman mammalian populations exposed to vehicle-only treatment in experimental Comparators studies or lower levels of TCDD in wildlife studies Primary outcomes: Male reproductive effects, including alterations in fertility; effects on sperm production, maturation, transport, morphology, or motility; malformations (hypospadias or cryptorchidism) or alterations in size, weight, morphology, histology, or function of male reproductive organs (testis, epididymis, seminal vesicle, prostate, vas deferens, or gubernaculum)
Read the entire page →
From page 170...
... ; altered age at puberty; adverse effects on lactation; premature reproductive senescence; female-associated Outcomes reproductive behaviors; and altered mammary gland development. Secondary outcomes: Indicators of female reproductive effects, including altered levels of endocrine or biochemical signaling molecules (androstenedione, dehydroepiandrosterone sulfate, estradiol, estrone, insulin-like growth factor-1, luteinizing hormone, sex hormone-binding globulin, and testosterone)
Read the entire page →
From page 171...
... b. In general, the primary outcomes are indicators of clinical effects that would be considered adverse whereas the secondary outcomes are considered surrogate measures (e.g., laboratory tests)
Read the entire page →

Key Terms

  • male reproductive
  • female reproductive
  • nonhuman mammals
  • statement element
  • populations exposed

  • biomonitoring data
  • restriction based
  • evidence population
  • reproductive organs
  • signaling molecules

  • restrictions based
  • lower levels
  • male nonhuman
  • utero exposure
  • including alterations

  • altered age
  • anogenital distance
  • including altered
  • comparators populations
  • human peco

  • mammary gland
  • mammals cause
  • vas deferens
  • human study
  • seminal vesicle

  • administered dose
  • humans associated
  • selected phthalates
  • animal study
  • altered levels


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.