Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals (2017) / Chapter Skim
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Appendix F: Supporting Materials for the PBDE (Human) Systematic Review
Appendix F: Supporting Materials for the PBDE (Human) Systematic Review
Pages 387-404
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From page 387... ...
During the course of exploring this class of chemicals, the committee learned of other systematic reviews on this topic and decided that using one of them could provide a case study of how to evaluate an existing review for risk of bias and how to update an existing review. OBJECTIVE AND SPECIFIC AIMS Review Question The overall objective of this systematic review is to answer the question is developmental exposure to PBDEs in humans associated with alterations in quantitative measures of intelligence or attentiondeficit/hyperactivity disorder (ADHD)
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PBDEs appear to fit this case criterion. Because the committee learned that other systematic reviews on PBDEs and human neurodevelopment are available, it decided to demonstrate how an existing systematic review can be evaluated for risk of bias and updated.
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The review team will be responsible for performing all aspects of the review, including conducting the literature searches; applying inclusion/exclusion criteria to screen studies; extracting data; assessing risk of bias for included studies; and analyzing and synthesizing data. The roles and responsibilities of the team members will be documented throughout the protocol.
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From page 390... ...
applied in the existing systematic review. Evidence Synthesis The review team will qualitatively synthesize the body of evidence for each outcome and, where appropriate, a meta-analysis will be performed.
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From page 391... ...
Type of data (e.g., continuous or dichotomous) , statistics presented in paper, access to raw data Variation in degree of risk of bias at individual study level The review team expects to require input from subject-matter experts to help assess the heterogeneity of the studies.
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Ellen Mantus is a scholar and director of risk assessment on the Board on Environmental Studies and Toxicology at the National Academies of Sciences, Engineering, and Medicine with more than 20 years of experience in the fields of toxicology and risk assessment. She has served as the study director on numerous projects, including ones that have assessed the health implications of various chemical exposures; developed strategies for applying modern scientific approaches in toxicology and risk assessment; provided guidance to federal agencies on risk-based decision making; and evaluated barriers to deployment of electric vehicles and associated charging infrastructure.
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terms and keyword synonyms will be developed. To assist in compiling these terms, the review team will consult an existing systematic review protocol studying PBDEs in humans (J.
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OR "2,2',4,4',5,5'‐ hexabrominated diphenyl ether"[Supplementary Concept] OR "hexabrominated diphenyl ether 153"[Supplementary Concept]
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OR "Continuous Performance Tests"[tw] OR "Continuous Performance Task"[tw]
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Her research interests are in the mechanisms of action of drugs as teratogens. She studies developmental toxicity using a combination of in vivo, in vitro, and mo lecular approaches with the goal of elucidating how the embryo responds to insult after direct or maternal exposure and the consequences to progeny of paternal drug exposure.
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2016. Associa tions between human exposure to polybrominated diphenyl ether flame retardants via diet and indoor dust, and internal dose: A systematic review.
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2016. Hair as Noninvasive Biomarkers of Human Exposure to Polybrominated Diphenyl Ethers (PBDEs)
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SECTION F-3 Results of Literature Searches for Human Studies on the Effects of Developmental Exposure to PBDEs on Intelligence or ADHD and Attention-Related Behavioral Conditions Literature searches were performed on September 28, 2016, using the search strategy presented in Lam et al.
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hospitals between all 11 2007 and 2008 Post-hoc Analysis of Prospective Birth Cohort Chao et al. 2011 Pregnant women Southern 70 mother- 28, 47, 99, 100, 153, BDE 47 range: X Bayley-III Cognitive, randomly recruited Taiwan child pairs 154, 183, 196, 197, 0.207-80.4 ng/g lipid Bayley-III Language from four local 203, 206, 207, 208, assessed at 8-12 months.
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study maternal report ADHD index and DSM-IV inattentive and hyperactivity/impulsivity subscales, BASC-2 maternal report hyperactivity scale and attention problems scale, Conners' rating scale teacher report ADHD index and DSM-IV inattentive and hyperactivity/impusivity subscales, BASC-2 teacher report hyperactivity scale and attention problems scale at 5 and 7 years.
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2001 and 2005 Roze et al. 2009 Pregnant women in Northern 62 mother- 47, 99, 100 BDE 47 range: X Child Behavior Checklist Groningen Infant providences child pairs |
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Cross-Sectional Study Gump et al. 2014 Children recruited Oswego 43 children 28, 47, 99, 100 BDE 47 range: X Parental Strengths and from another ongoing County, New |
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