Animal Models for Microbiome Research Advancing Basic and Translational Science: Proceedings of a Workshop (2018) / Chapter Skim
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Mouse microbiome models have also been the primary choice for performing preclinical proof-of-concept tests of causal relationships between given community configurations/memberships and host physiological, metabolic, immune, and neurologic phenotypes and for developing methods to repair or prevent functional abnormalities in these communities that contribute to disease pathogenesis. The mouse, however, is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli.
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BOX 1-1 Workshop Statement of Task An ad hoc committee will plan and conduct a public workshop that will provide an overview of the state of the art of microbiome research using animal models. Joshua Lederberg explained that the "microbiome signi fies the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space and have been all but ignored as determinants of health and disease." Most of the animal based, microbiome-related research depends on murine models to im prove our understanding of the physiology, pathology, and relationship to health and disease at both the animal and the translational levels.
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