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Public Health Consequences of E-Cigarettes (2018) / Chapter Skim
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Summary Annex Report Conclusions by Level of Evidence
Pages 17-22

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From page 17...
... There is conclusive evidence that, other than nicotine, the number, quantity, and characteristics of potentially toxic substances emitted from e-cigarettes are highly variable and depend on product characteristics (including device and e-liquid characteristics) and how the device is operated.
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From page 18...
... There is substantial evidence that components of e-cigarette aerosols can promote formation of reactive oxygen species/oxidative stress. Although this supports the biological plausibility of tissue injury and disease from long-term exposure to e-cigarette aerosols, generation of reactive oxygen species and oxidative stress induction is generally lower from e-cigarettes than from combustible tobacco cigarette smoke.
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From page 19...
... • Conclusion 18-2. There is substantial evidence that completely switching from regular use of combustible tobacco cigarettes to e-cigarettes results in reduced short-term adverse health out comes in several organ systems.
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From page 20...
... • Conclusion 10-2. There is limited evidence from in vivo animal studies using intermediate biomarkers of cancer to support the hypothesis that long-term e-cigarette use could increase the risk of cancer; there is no available evidence from adequate long-term animal bioassays of e-cigarette aerosol exposures to inform cancer risk.
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From page 21...
... • Conclusion 18-4. There is insufficient evidence that e-cigarette use changes short-term adverse health outcomes in several organ systems in smokers who continue to smoke combustible tobacco cigarettes (dual users)
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Key Terms

  • tobacco cigarettes
  • limited evidence
  • conclusive evidence
  • substantial evidence
  • moderate evidence

  • insufficient evidence
  • tobacco cigarette
  • available evidence
  • toxic substances
  • subsequent combustible

  • evidence suggesting
  • nicotine intake
  • cigarette smoking
  • bustible tobacco
  • effects including

  • affect cell
  • increases risk
  • lower compared
  • including device
  • peripheral artery

  • artery disease
  • cell dysfunction
  • pressure increases
  • heart rate
  • acute endothelial

  • cigarette smoke
  • dermal contact
  • endothelial cell
  • induce acute
  • cell damage


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