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Public Health Consequences of E-Cigarettes (2018) / Chapter Skim
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15 Research Needs: Effects of E-Cigarettes on Health
Pages 481-486

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From page 481...
... Specific items for consideration identified by the committee are noted for each of these and are not listed in any priority order. ADDRESSING GAPS IN SUBSTANTIVE KNOWLEDGE Recommendation 15-1: The committee recommends that the Food and Drug Administration and other federal research spon sors and/or device manufacturers prioritize e-cigarette research that addresses key gaps regarding health effects in individuals.
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From page 482...
... • The effect of e-cigarette aerosol on pulmonary inflammation and clearance of viral and bacterial pathogens in the lungs should be studied in appropriate animal models following inhalation exposures. Short-Term Human Studies with Clinically Relevant Biomarkers • Particle deposition in the human airways should be evaluated to assess where e-cigarette–derived particles impact the upper versus lower airways and alveoli, and how area of impaction in the lung may influence health effects caused by e-cigarettes.
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From page 483...
... Longer-Term Clinical and Epidemiological Studies • Longitudinal cohort studies should be done to assess the associa tion of long-term use of e-cigarettes with clinical and subclinical cardiovascular, respiratory, and other health outcomes as com pared with smoking combustible tobacco cigarettes, dual use of e-cigarettes and combustible tobacco cigarettes, and never smok ing or vaping. • Because prospective studies for clinical disease take very long, cross-sectional studies of e-cigarette use with subclinical mea sures of cardiovascular disease and respiratory diseases can be very useful.
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From page 484...
... • Effective communication strategies about the relative risk of e ­-cigarettes compared with combustible tobacco products are needed. IMPROVING RESEARCH METHODS AND QUALITY Recommendation 15-2: The committee recommends that the Food and Drug Administration and other federal research sponsors and/or device manufacturers prioritize research that improves the quality of e-cigarette research on health outcomes.
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From page 485...
... • For cohort studies, the age of the study population is important, as the age should be adequate in order to study cancer or cardio respiratory outcomes, but not so old that it can cause difficulty in distinguishing the health effects of cigarette smoking versus e-cigarettes. • Develop guidelines for reporting studies on e-cigarette use to standardize the published information and ensure that the studies are useful to understand the health effects of e-cigarette products and to inform product evaluation and regulation.
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Key Terms

  • epidemiological studies
  • cardiovascular disease
  • tobacco products
  • tobacco cigarettes
  • animal studies

  • inhalation exposure
  • cohort studies
  • respiratory diseases
  • longitudinal cohort
  • manufacturers prioritize

  • tobacco smoke
  • relevant biomarkers
  • improving research
  • substantive knowledge
  • research methods

  • committee identified
  • animal models
  • study population
  • device manufacturers
  • clinical outcomes

  • addressing gaps
  • specific items
  • vitro mechanistic
  • respiratory disease
  • nih electronic

  • human clinical
  • smoking combustible
  • recruit additional
  • knowledge recommendation
  • subclinical cardiovascular


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