Review of Report and Approach to Evaluating Long-Term Health Effects in Army Test Subjects (2018) / Chapter Skim
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4 Strategy for Evaluating Potential Long-Term Health Effects in Army Test Subjects
4 Strategy for Evaluating Potential Long-Term Health Effects in Army Test Subjects
Pages 35-42
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From page 35... ...
Figure 4-1 illustrates the steps of the strategy, and the elements and potential options in each step are shown in Figure 4-2. STEP 1: AGENT PRIORITIZATION In the report Assessment of Potential Long-Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances: Literature Review and Analysis (the Report)
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From page 36... ...
For example, the agents identified in the Report as having potential long-term health effects could also be used as a basis for setting priorities. Step 1: Agent prioritization Step 2: GO to Step 6: Problem formulation Authoritative hazard assessment available Step 3: Literature search and screening STOP Insufficient evidence for Step 4: hazard ID Data analysis and synthesis Step 5: Evidence integration Step 6: Hazard ID conclusions FIGURE 4-1 Proposed steps of a strategy to evaluate and categorize potential long-term health effects of biological and chemical agents, drugs, medications, and substances.
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From page 37... ...
, and strength of association FIGURE 4-2 Proposed steps of a strategy to evaluate and categorize potential long-term health effects of biological and chemical agents, drugs, medications, and substances. Abbreviations: ACGIH, American Conference of Governmental Industrial Hygienists; ATSDR, Agency for Toxic Substances and Disease Registry; EPA, U.S.
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From page 38... ...
It might be helpful for the Army to identify the health effects by the most recent International Classification of Diseases (ICD-10) codes, as described by the National Center for Health Statistics.
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From page 39... ...
Specifying the methods before conducting the review helps to ensure transparency and objectivity in identifying the relevant scientific literature. For literature searches, a search strategy is developed that typically identifies the databases to be searched, the time period for the searches, and the search terms (e.g., CAS numbers and synonyms for the agents, keywords for capturing the health effects, and route of exposure)
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From page 40... ...
For example, the evidence integration approaches used by the Institute of Medicine (IOM, 2000, 2012; NASEM, 2016) to draw causality conclusions rely primarily on epidemiological evidence whereas the NTP (2015)
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From page 41... ...
2016. Assessment of Potential Long-Term Health Effects on Army Human Test Subjects of Relevant Biological and Chemical Agents, Drugs, Medications and Substances: Literature Review and Analysis.
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From page 42... ...
Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences [online]
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