Progress Toward Transforming the Integrated Risk Information System (IRIS) Program A 2018 Evaluation (2018) / Chapter Skim
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Appendix E: Committee Findings Regarding 2014 Recommendations
Appendix E: Committee Findings Regarding 2014 Recommendations
Pages 110-119
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Appendix E Committee Findings Regarding 2014 Recommendations 110
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specifically complete documents, such as the The revised handbook was not provided to the committee. EPA staff Slides 21‒22 draft handbook, that provide detailed guidance for developing indicated that the handbook is under internal agency review and that Systematic Review Protocol for IRIS assessments.
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;b that person has an MS in library and information science 11 3 EPA should include protocols for all systematic reviews The IRIS program has developed draft systematic-review protocols Systematic Review Protocol for conducted for a specific IRIS assessment as appendixes to the that are undergoing public comment before being made final. The the IRIS Chloroform Assessment assessment.
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14 4 Evidence identification should involve a predetermined search EPA systematic-review protocols contain descriptions of how Systematic Review Protocol for the of key sources, follow a search strategy based on empirical evidence will be identified, including relevant search terms and IRIS Chloroform Assessment research, and be reported in a standardized way that allows databases to be queried. (Inhalation)
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17 4 EPA should engage information specialists trained in The IRIS assessment team includes an information specialist. The Systematic Review Protocol for the systematic reviews in the process of evidence identification, specific tasks completed by that person are not clear.
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Draft Systematic Review Protocol for the establish empirically supported criteria for animal or protocols describe the domains to be considered in the evaluation of IRIS Chloroform Assessment mechanistic studies, an IRIS assessment needs to include a epidemiology studies and animal toxicity studies. Domain ratings (Inhalation)
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IRIS systematic- IRIS Chloroform Assessment characteristics of included studies. review protocols also indicate that decisions are made on an (Inhalation)
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pyrenee chemical's posing a hazard should be made as explicit as is described as ranging from "strongest evidence for human possible, should be connected explicitly to evidence tables hazards" to "less robust evidence." Workshop discussion and the Systematic Review Protocol for the produced in previous stages of the IRIS process, and should chloroform protocol show progress in template development. EPA IRIS Chloroform Assessment consider all lines of evidence (human, animal, and mechanistic)
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For that purpose, use by risk managers. The IRIS program considers the quality of 2012 IRIS Toxicological Review of EPA will need to develop a clear set of criteria for judging the studies when deciding which studies will be advanced for Tetrachloroethylened relative merits of individual mechanistic, animal, and quantitative dose‒response modeling; studies rated as having epidemiologic studies for estimating human dose-response medium or high confidence will be advanced for dose‒response Workshop demonstrations of HAWC relationships.
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2018. Systematic Review Protocol for the IRIS Chloroform Assessment (Inhalation)
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