Veterans and Agent Orange Update 11 (2018) (2018) / Chapter Skim
Currently Skimming:
1 Introduction
1 Introduction
Pages 17-24
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From page 17... ...
The National Academies was also asked to recommend, as appropriate, additional studies needed to resolve continuing scientific uncertainties related to health effects and herbicide exposures and to comment 1 Despite loose usage of "Agent Orange" by many people, in numerous publications, and even in the title of this series, this committee uses "herbicides" to refer to the full range of herbicide exposures experienced in Vietnam, while "Agent Orange" is reserved for a specific one of the mixtures sprayed in Vietnam.
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From page 18... ...
Each report in the VAO series contains detailed reviews of the scientific studies evaluated by the committees and their implications for cancers, reproductive and developmental effects, neurologic disorders, and other health effects. VA has specified particular areas of focus for each update, for example, the Update 2 Since March 2016, the Health and Medicine Division of the National Academies has continued the consensus studies and convening activities previously undertaken by the Institute of Medicine (IOM)
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From page 19... ...
A VA representative delivered the charge to the committee during the open session of the committee's first meeting. In addition to the standard language of assessing associations between health outcomes and exposures to chemicals present in the herbicides used by the military in Vietnam that all VAO update committees are charged with reviewing, the committee for this final update was asked to assess three health outcomes in particular: possible generational effects on the descendants of male Vietnam veterans that may be the result of exposure to any of the COIs, myeloproliferative neoplasms, and glioblastoma multiforme.
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From page 20... ...
] It will also assess the current research available on possible generational health effects that may be the result of exposures to these chemicals -- including the biologic plausibility or potential for an exposure to lead to an increased risk of birth defects or other adverse conditions in the descendants of male veterans -- and will address myeloproliferative neoplasms (MPNs)
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From page 21... ...
As has been the practice of previous VAO committees, the committee held three open sessions not only to gather additional information from people who have particular expertise on topics and subjects that arise during deliberations (such as VA researchers, experts in glioblastoma multiforme, and specialists in environmental exposures and heritable health effects) , but also especially to listen to individual Vietnam veterans and others, such as spouses and other family members and veterans service organization advocates, who are concerned about aspects of health that may be service-related.
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From page 22... ...
Chapter 6, the first of the chapters evaluating epidemiologic evidence concerning particular health outcomes, addresses immunologic effects and discusses the reasons for what might be perceived as a discrepancy between a clear demonstration of immunotoxicity in animal studies and a paucity of human epidemiologic studies with similar findings. Its placement in the report reflects the committee's belief that immunologic changes may constitute an intermediate step in the generation of distinct clinical conditions, as discussed in subsequent chapters.
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From page 23... ...
, the committee reported on the status of recommendations made throughout the VAO series. In the interest of minimizing unnecessary repetition, the citations for all chapters have been merged into a single reference list that follows all of the chapters.
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