Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research Proceedings of a Workshop (2019) / Chapter Skim
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2 Context for the Use of Marmosets as Animal Models
2 Context for the Use of Marmosets as Animal Models
Pages 5-10
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From page 5... ...
research facilities from wild populations in South American countries such as Brazil, Colombia, Peru, and Venezuela. Marmosets from the same areas were more commonly imported to the 5
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Marmosets were used for studies in a wide range of areas including reproduction, biodefense, and gene therapy. CURRENT USE AND KEY ADVANTAGES In the 1980s and 1990s, researchers began to use marmosets more and more in neuroscience, behavior, and physiology inquiries, as well as stem cell research and assisted reproductive technologies.
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A second driver of increased demand for marmosets is transgenics and gene editing, in particular gene editing techniques such as clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)
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While deforestation is probably the main driver of animal endangerment, exports for biomedical research have likely played an unfortunate role in the declines of some species, such as the cotton-top tamarin. Thus, current import controls will favor wild populations, even though it does make it harder for researchers to acquire marmosets.
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From page 9... ...
This is particularly important as interest in transgenic work grows and larger colonies are developed. REFERENCES de Souza Fialho M, Ludwig G, Valenca-Montenegro MM.
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