Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research Proceedings of a Workshop (2019) / Chapter Skim
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6 Marmoset Supply and Availability
6 Marmoset Supply and Availability
Pages 51-60
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From page 51... ...
MARMOSETS IN THE WILD Maria Adélia Borstelmann de Oliveira, a professor at the Animal Ecophysiology and Behavior Laboratory of the Federal Rural University of Pernambuco in Brazil, and Joanna Malukiewicz addressed the status and habits of marmosets in the wild. Brazil's Wild Marmoset Populations Six marmoset species are part of the genus Callithrix, a relatively young genus under 2.5 million years old (see Figure 6-1)
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From page 52... ...
52 CARE, USE, AND WELFARE OF MARMOSETS FIGURE 6-1 Marmoset genera Callithrix and Mico. SOURCES: Maria Adélia Borstelmann de Oliveira.
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From page 53... ...
In the state of Pernambuco, at least two areas where common marmosets live, are under invasion by the Amazonian squirrel monkey, Saimiri sciureus. Borstelmann de Oliveira described the increased stress and behavioral change of the marmosets in the presence of the larger, and also highly insectivorous, squirrel monkeys, as shown by high levels of fecal cortisol of this population.
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From page 54... ...
Researchers in Brazil are advancing knowledge in this area by comparing captive and wild marmoset behavior, including studies of gum eating, social and foraging behavior, and sensorial ecology. One study is examining the diet, food competition, and lipid profiles of both captive and wild marmosets; another has concluded that wild marmosets in competition for resources have a higher level of cortisol than captive marmosets or wild marmosets without competition.
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From page 55... ...
During the discussion an attendee noted that another sign of this increased demand is the sharp increase in references to marmosets in the Society for Neuroscience annual conference programs FIGURE 6-2 U.S. imports of macaques (left axis, blue bars)
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From page 56... ...
, marmoset demand is also on the rise because they are well suited for emerging transgenic and gene editing techniques. One WNPRC study is using CRISPR/Cas9 gene editing approaches to develop a marmoset model for familial Parkinson's disease, a process extending over multiple generations of animals that involves much trial and error.
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From page 57... ...
These include the establishment of centralized breeding facilities, a centralized pedigree tracking system and animal locator, and a quarantine facility for imported animals. The consortium also hopes to improve overall communication, especially with South American colleagues closest to wild marmoset populations, and identify best practices for marmoset transportation and care.
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From page 58... ...
The panel was charged to forecast the future of NHPs in biomedical research, assess existing resources and infrastructure and the potential need for expansion, and identify key challenges. Challenges identified include funding, space, and infrastructure limitations; a lack of standardized data collection and reporting; and needs related to personnel training.
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From page 59... ...
1994. Nonsurgical uterine stage preimplantation embryo collection from the common marmoset.
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