Traumatic Brain Injury A Roadmap for Accelerating Progress (2022) / Chapter Skim
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Appendix A: Highlights of Selected Recent TBI Research Efforts
Appendix A: Highlights of Selected Recent TBI Research Efforts
Pages 179-192
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From page 179... ...
RESEARCH PRIORITY-SETTING EFFORTS The diversity of the TBI research landscape mirrors the diversity of populations impacted by TBI, from military personnel (Veterans, active duty military personnel, cadets and military trainees) , to athletes (professional, collegiate, student, youth)
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From page 180... ...
Other TBI initiatives address crosscutting issues and include all or more than one of these population groups. For instance, the needs of athletes and their coaches to assess potential TBI in high-pressure scenarios share some similarities with the needs of military medical staff assessing potential TBI in combat; the challenges of mild TBI are of similar significance in civilian and military settings; the study of TBI among aging Veterans may offer insights into the impacts of TBI among aging civilians; and novel advances in classification and measurement could improve the sensitivity of all TBI research, while efforts to promote data interoperability similarly affect all research settings.
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From page 181... ...
• "Phenotyping the Spectrum of Traumatic Brain Injury: A Review and Pathway to Standardization" (Pugh et al., 2021) • "Biomarker Development to Advance Diagnosis and Treatment of Traumatic Brain Injury" • "Designing Successful Clinical Trials for Traumatic Brain Injury" • "A Review of Implementation Concepts and Strategies Surrounding Traumatic Brain Injury Clinical Care Guidelines" (Lumba-Brown et al., 2021)
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From page 182... ...
present TBI clinical research Pediatric Common CIHR 2013–2018 Pediatric TBI Effort to create an assessment Data Elements (PED- patients battery to advance clinical TBI CDE) Federal Interagency DoD, VA, NIH 2011– Military personnel Centralized TBI research database TBI Research (FITBIR)
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From page 183... ...
patients over the age of 14 • HOBIT (Hyberbaric Oxygen Brain Injury Treatment Trial) 11 -- study for adults aged 16–65 years with severe TBI The Big Ten-Ivy League Concussion Taskforce12 is a network and database established in 2012 to improve understanding of sport-related concussion and TBI.
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From page 184... ...
.16 The DoD TBI Center of Excellence (TBICoE) 17 (originally called the Defense and Veterans Brain Injury Center)
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From page 185... ...
Notably, the project has resulted in the development of a blood test to detect brain injury. Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT)
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From page 186... ...
NeuroTruama Sciences LLC, Abbott Laboratories TBI Endpoint Development Initiative (TED) DoD, FDA, PPPs 2014–present NOTE: CENC = Chronic Effects of Neurotrauma Consortium; CHEO = Children's Hospital of Eastern Ontario; DoD = Department of Defense; FDA = Food and Drug Administration; GFAP = glial fibrillary acidic protein; HHS = Department of Health and Human Services; NCAA = National Collegiate Athletic Association; NIDILRR = National Institute on Disability, Independent Living, and Rehabilitation Research; NIH = National Institutes of Health; NIMH = National Institute of Mental Health; NINDS = National Institute of Neurological Disorders and Stroke; PPP = public–private partnership; TBI = traumatic brain injury; UCH-L1 = ubiquitin carboxy-terminal hydrolase-L1; UCSD = University of California, San Diego; USAMMDA = U.S.
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From page 187... ...
Military service members Longitudinal study of outcomes after inpatient rehabilitation at 5 VA Polytrauma and Veterans Rehabilitation Centers Preclinical Studies to explore TBI drugs and biomarker screening Military personnel Studies and database to support development of comprehensive TBI strategies Pediatric populations International efforts to study the impact of server mild TBI (mTBI) interventions Military personnel Multicomponent studies to generate evidence-based recommendations Military Veterans Study to investigate the long-term effects of mTBI among military service personnel and Veterans Military Veterans Further research for TBI military personnel and Veterans; newest iteration of CENC Student athletes and Study to explore concussive injury and recovery cadets Adults with moderate to Study to evaluate the utility of Banyan UCH-L1/GFAP detection assay mild TBI College football players Prospective cohort study to evaluate concussions among college football players Pediatric populations Study to develop indicators for pediatric persistent postconcussive symptoms Civilians Largest-scale initiative to analyze clinical TBI data and TBI outcomes Civilians, athletes, military Efforts to identify/validate measures of TBI and recovery personnel
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From page 188... ...
The TBI Endpoint Development (TED) Initiative29 began in 2014 with the aim of identifying and validating measures of brain injury and recovery for use in clinical trials to enable the development of precision TBI treatment.
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From page 189... ...
. 34 More information about DoD protocols for TBI assessment is available at DoD Clinical Recommendation January 2021, Progressive Return to Activity Following Acute Concussion/Mild Traumatic Brain Injury.
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From page 190... ...
guidelines for TBI care committees Stanford University, Brain Trauma Foundation DoD protocols for Military personnel Guidelines for military TBI assessment and personnel who experience return to duty mTBI International 2001– Sports participants Forum developed to conduct consensus present systematic TBI evidence review conferences and every 4 years statements on concussion in sport Guidelines for ANN, ACRM, 2018 Persons with Recommendations for patients disorders of NIDILRR prolonged disorders with prolonged disorders of consciousness of consciousness consciousness Pediatric mTBI CDC CDC 2018 Children with mTBI Guidelines for pediatric mTBI Resources Note: AANS = American Association of Neurological Surgeons; ACRM = American Congress of Rehabilitation Medicine; ANN = American Academy of Neurology; CDC = Centers for Disease Control and Prevention; CNS = Congress of Neurological Surgeons; DoD = Department of Defense; mTBI = mild traumatic brain injury; NIDILRR = National Institute on Disability, Independent Living, and Rehabilitation Research; TBI = traumatic brain injury. in 2001, and its sixth conference is scheduled for 2022.
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From page 191... ...
The most recent request for proposals issued by the CDMRP in Traumatic Brain Injury and Psychological Health, released in August 2021, indicated that $175 million had been allocated to the program.40 REFERENCES Baldwin, G., M Breiding, and D
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From page 192... ...
2018. Multi Center pre-clinical consortia to enhance translation of therapies and biomarkers for traumatic brain injury: Operation brain trauma therapy and beyond.
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