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The Future of Low Dose Radiation Research in the United States Proceedings of a Symposium (2019) / Chapter Skim
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5 Lessons Learned from Coordinated Research in Other Fields
Pages 59-66

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From page 59...
... fields that can help the radiation research community draw lessons to be learned for organizing a cohesive low dose radiation research program. Four different approaches in two research fields -- air pollution and genomic studies -- were described in some detail at the symposium.
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From page 60...
... presenting on models for funding research in health effects of air pollution. Seated at the table from left to right are Dr.
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From page 61...
... Funding for PM research continues today within EPA's Air, Climate, ­ and Energy Research Program and was approximately $95 million in fiscal year 2019. 5.1.2 The Health Effects Institute HEI is an independent, nonprofit corporation specializing in research on the health effects of air pollution.
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From page 62...
... It also periodically performs scientific reviews; currently HEI is undertaking a systematic review of the literature on the health effects of exposure to traffic. HEI-funded results are publicly available.2 Mr.
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From page 63...
... described two large-scale biology initiatives and discussed the relevance of several lessons learned for setting up a low dose radiation research program in the United States. 5.2.1 The Cancer Genome Atlas (TCGA)
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From page 64...
... She said that to successfully complete the project there was a need to • Organize the functions of the project into an integrated whole; • Obtain high-quality biosamples (which turned out to be a major challenge) ; • Integrate different disciplines and technologies into functional teams and results; • Transition from existing sequencing technologies to more sophisti cated approaches; • Build a new generation of analysis teams to carry out the project; • Resolve policy issues related to data access and informed consent; and • Communicate about TCGA to the cancer research community and provide opportunities for comments, input, or questions.
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From page 65...
... Through its efforts, the I-SPY 2 team has also produced sufficient data to establish a surrogate endpoint, pathologic complete response, which was approved by FDA in 2014 for use in breast cancer clinical trials.
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Key Terms

  • coordinated research
  • dose radiation
  • low dose
  • research progress
  • breast cancer

  • airborne particulate
  • scientific uncertainties
  • cancer research
  • reduce scientific
  • effects institute

  • unreasonable risk
  • arizona state
  • dan greenbaum
  • vehicle emissions
  • anna barker

  • particulate matter
  • epa administrator
  • greenbaum noted
  • initial research
  • genome research

  • energy research
  • funding research
  • assessed research
  • matter research
  • pollution research

  • evaluating research
  • research called
  • health research
  • science relevant
  • scientific reviews


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