Heritable Human Genome Editing (2020) / Chapter Skim
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Appendix B: Commissioner Biographies
Appendix B: Commissioner Biographies
Pages 193-202
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From page 193... ...
His work uses human genetics and genomics to understand fundamental mechanisms underlying a wide range of human diseases. He is well known for his discovery that mutations with large effect on human blood pressure act by altering renal salt reabsorption, discoveries that have informed dietary guidelines and therapeutic strategies used worldwide to reduce blood pressure and prevent heart attacks and 193
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From page 194... ...
He has received numerous awards for his research, including the 2014 Breakthrough Prize in Life Sciences, the 2008 Wiley Prize, and the highest scientific awards of the American Heart Association, the American and International Societies of Nephrology, and the American and International Societies of Hypertension. He has received honorary doctorates from Northwestern University, Mount Sinai School of Medicine, and Yale University.
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From page 195... ...
His laboratory pioneered the development of zinc-finger nucleases as gene targeting tools, and he continued working with the more recent Transcription activator–like effector nucleases (TALENs) and CRISPRCas nucleases, with much of the effort focused on optimizing the efficiency of these reagents for targeted mutagenesis and gene replacement.
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From page 196... ...
He is also the founding director of the UKM Medical Molecular Biology Instiute at t the UKM, Kuala Lumpur, and a professor of pediatric oncology and hematology, and molecular biology.
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From page 197... ...
Dracopoulos irector D of the Johns Hopkins Berman Institute of Bioethics, a position he assumed in 2016. He is the inaugural Robert Henry Levi and Ryda Hecht Levi Professor of Bioethics and Public Policy and professor in the Department of Health Policy and Management of the Johns Hopkins Bloomberg School of Public Health.
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From page 198... ...
Dr. Lander has received numerous honors including the MacArthur Fellowship, the Breakthrough Prize in Life Sciences, the Albany Prize in Medicine and Biological Research, the Gairdner Foundation International Award (Canada)
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From page 199... ...
Dr. Li has shown that this technology can be used as a unique tool for genetic analyses in mice, including medium-scale targeted screening of crucial genes or essential nucleotides of a specific gene involved in a developmental process; efficient generation of mouse models carrying defined point mutations related to human developmental defects; and one-step generation of mouse models that mimic multiple genetic defects in human diseases.
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From page 200... ...
Her current work focuses on Ayurgenomics, an innovative approach of combining the doctrines of Ayurveda, the Indian system of medicine for deep phenotyping of individuals, with contemporary genome analysis tools to address the phenotypic heterogeneity limiting our understanding of the genetics of common complex disorders; and functional genomics of rare genetic variants using cellular models of disease and CRISPR-based genome editing tools. In her persistent efforts to translate benefits of science to society, Dr.Thelma established early on the DNA-based diagnosis for fragile X syndrome and, more recently, newborn screening for inborn errors of metabolism to reduce the socio-economic burden of this large group of genetic disorders in the country.
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From page 201... ...
The Wang laboratory focuses on developing novel technologies to achieve efficient and specific genome engineering, and applyng them to study the function of genes and establish novel therapeutic i methods. His laboratory has developed a zygote electroporation of nuclease method to generate genetically modified mouse models with high throughput and efficiency, the Casilio method to regulate gene transcription, and a method to generate CAR-T cells with multiplex gene editing.
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