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Rapid Expert Consultation
Pages 1-6

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From page 1...
... the optimal duration of isolation of cases. Members of the National Academies of Sciences, Engineering, and Medicine's Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats who were instrumental in preparing this response include Peter Daszak, EcoHealth Alliance; Diane E
From page 2...
... 5 RNA can be detected from infectious virus or from remnants of virus that are no longer infectious. In a patient recovering from an illness who was previously PCR positive, at least two sequential negative tests for viral RNA is a reasonable indicator of when infectious virus is no longer being shed.
From page 3...
... 9,10,11,12,13 More severe clinical disease is associated with longer persistence of viral RNA shedding and may represent a significant occupational transmission risk for health care workers. 14,15 Viral RNA shedding for up to a week after the resolution of symptoms is common and in one case has been documented to continue for as long as 49 days although this viral RNA may not represent infectious virus.
From page 4...
... 24 During the SARS epidemic in Hong Kong in 2003, the virus was spread in an apartment complex (Amoy Gardens) due to aerosolized waste flushed from toilets that found its way into the air of other apartments through poorly designed bathroom floor drains.
From page 5...
... This would best be done in multiple geographies, with diverse age classes, ethnic background, etc. • Evidence of waning antibody titer can be anticipated after 2 years, but any indication of earlier significant drop in titers per age class or other grouping would be very important to identify because it might affect vaccine efficacy, the ability of these people to be re infected and the potential for disease attenuation with an anamnestic response.
From page 6...
... APPENDIX Authors and Reviewers of This Rapid Expert Consultation This rapid expert consultation was prepared by staff of the National Academies of Sciences, Engineering, and Medicine, and members of the National Academies' Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats: Peter Daszak, EcoHealth Alliance; Diane E Griffin, Johns Hopkins Bloomberg School of Public Health; Kent E


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