Rapid Expert Consultations on the COVID-19 Pandemic March 14, 2020-April 8, 2020 (2020) / Chapter Skim
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Rapid Expert Consultation Update on SARS-CoV-2 Surface Stability and Incubation for the COVID-19 Pandemic (March 27, 2020)
Rapid Expert Consultation Update on SARS-CoV-2 Surface Stability and Incubation for the COVID-19 Pandemic (March 27, 2020)
Pages 15-24
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From page 15... ...
Office of Science and Technology Policy Executive Office of the President Eisenhower Executive Office Building 1650 Pennsylvania Avenue, NW Washington, DC 20504 Dear Dr. Droegemeier: You requested an update and elaboration on our previous rapid expert consultation dated March 15, concerning issues of virus survival on surfaces and in the air, and virus/disease incubation period.
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From page 16... ...
Chad Roy from the Tulane University National Primate Research Center shared via telephone some preliminary results of dynamic aerosol stability experiments with SARS-CoV-2 conducted over the past several weeks at the Infectious Disease 1 Chin et al.
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From page 17... ...
, part of the National Institutes of Health, current studies include the effect of temperature and humidity on virus stability; virus stability in human body fluids, including urine and feces; and the effectiveness of decontamination procedures for PPE, including N95 respirators.5 As follow-up, the study by van Doremalen et al. mentioned in our rapid expert consultation on March 15, which was at that time an unpublished preprint, has since been published by the New England Journal of Medicine.6 B
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From page 18... ...
However, the lack of detection of the virus in air samples does not necessarily contradict the finding of the virus on the air outlet fan in Patient C's room, which presumably deposited from air onto the surface of the fan. There are at least three explanations for the negative findings in air: (1)
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From page 19... ...
Of note, air collectors positioned more than 6 feet from each of two patients yielded positive samples, as did air samplers placed outside patient rooms in the hallways. Although the results are preliminary, it appears that some samples are positive for infectious virus, including an air sample collected well more than 6 feet from a patient.11 These results require urgent confirmation under a variety of conditions as they have significant implications for current public health messaging regarding necessary distancing between nearby individuals to prevent virus transmission.
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From page 20... ...
Although viral RNA was detected in many environmental samples across the various studies, infectivity is not known. It is important to note that there are no available data to our knowledge that speak to the possible linkage between the presence of environmental viral RNA or even infectious virus and the risk of transmission from these environmental sites to humans.
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From page 21... ...
experimental studies, typically involving the inoculation of animals in the laboratory using a laboratory-propagated virus under controlled conditions and subsequent monitoring for onset of viral shedding, signs of disease, or other physiological responses; and (B) natural history studies, typically involving longitudinal or cross-sectional studies of naturally exposed humans and the collection of data on time of exposure and time of onset of signs, symptoms, and virological and molecular features of infection and disease.
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From page 22... ...
In a recent preprint from the National Institute of Allergy and Infectious Diseases, Peking University, and the Chinese Center for Disease Control and Prevention, Qin et al. identified asymptomatic individuals at their time of departure from Wuhan and followed them until symptoms arose.16 This method was reported to offer enhanced accuracy by reducing recall bias and by utilizing forward time data.
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From page 23... ...
. Given the small number of human studies evaluating these disease characteristics for COVID-19, additional studies to confirm incubation period estimates and infectiousness prior to symptom onset are urgently needed.
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