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Genomic Epidemiology Data Infrastructure Needs for SARS-CoV-2 Modernizing Pandemic Response Strategies (2020) / Chapter Skim
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Summary
Pages 1-8

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 1...
... Department of Health and Human Services' Office of the Assistant Secretary for Preparedness and Response and Office of Science and Technology Policy requested that the National Academies of Sciences, Engineering, and Medicine convene an ad hoc committee to lay out a framework to define and describe the data needs for a system to track and correlate viral genome sequences with clinical and epidemiological data. Such a system would help ensure the integration of data on viral evolution with detection, diagnostic, and countermeasure efforts.
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From page 2...
... In the United States, the U.S. Centers for Disease Control and Prevention's SARS-CoV-2 Sequencing for Public Health Emergency Response, Epi­demiology, and Surveillance consortium is working to coordinate a nationwide genomic sequencing effort.
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From page 3...
... Currently, no central repository exists for the collection and curation of infectious disease outbreak data from multiple sources such as federal, state, and local public health agencies; health care networks; and public health and clinical laboratories. In order to create a more integrated data system, insights can be gleaned from existing efforts to integrate data.
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From page 4...
... Is resistance to Changes in viral Hospital or health care antiviral drugs or genome associated center data on patients other treatments with failure to who do not respond to changing? respond to treatment therapy or show failure of treatment Is there altered escape Changes in viral Hospital data on from the host immune genome associated patients who show response/within host with persistence prolonged shedding evolution?
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From page 5...
... The U.S. Department of Health and Human Services should develop and invest in a national data infrastructure sys tem that constructively builds on existing programmatic i­nfrastructure with the ability to accurately, efficiently, and safely link genomic data, clinical data, epidemiological data, and other relevant data across mul tiple sources critical to a public health response such as the current SARS-CoV-2 outbreak.
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From page 6...
... infrastructure to assess the annual risk of seasonal influenza, work could improve usability and coverage of health information exchanges, and other initiatives) , and ­ensure i­nclusion of entities with supporting functions across scales -- ­including private health care systems that provide data or state and local public health laboratories that collect data -- in ongoing system development and evaluation.
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From page 7...
... The U.S. Department of Health and Human Services should establish an effective and sustainable science-driven leadership and governance structure for the use of SARS-CoV-2 genome sequences in addressing critical national public health and basic science issues, develop a national strategy, and ensure the funding needed for successful execution of the strategy.
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Key Terms

  • clinical data
  • sequence data
  • genome sequences
  • data infrastructure
  • genome sequence

  • genomic epidemiology
  • viral genome
  • genomic data
  • viral sequence
  • ebola virus

  • genome associated
  • viral load
  • correlate viral
  • health laboratories
  • national strategy

  • local public
  • respiratory syndrome
  • sequences linked
  • tiple sources
  • state laws

  • global initiative
  • national data
  • including data
  • influenza data
  • big data

  • ferent data
  • viral epidemics
  • associated data
  • outbreak data
  • integrating data


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