Army Medical Research and Development Infrastructure Planning Proceedings of a Workshop (2021) / Chapter Skim
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Approaches for Improving Army Medical Infrastructure Planning
Approaches for Improving Army Medical Infrastructure Planning
Pages 18-33
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From page 18... ...
A complicated p roject is the Predicting Health and Disease program, which has the goal of keeping the fighting force 100 percent available by identifying sickness early so that the military billet can be filled with mission-ready persons. Humans can exhibit subclinical signs of illness, which can be detected with near certainty days before becoming symptomatically ill from a virus -- nformation that can be used to employ appropriate i t herapeutics or take administrative actions.
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Referring to the cyclical pattern of wartime improvement in medical support followed by postwar performance dips, which represent potential lives lost, he identified the three recurring themes: (1) postwar military reductions falling disproportionately on medical services, (2)
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20 Large Scale Batch Manufacturing Facility Miniaturized Continuous Manufacturing Machine Future: Stand alone machine producing Thousands of square feet Total area: 400 ft2 multiple drugs on demand FIGURE 4 Paradigm shift: On demand pharmaceuticals are transforming drug manufacture. SOURCE: Geoff Ling, NED Biosystems, presentation to the workshop.
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NOTE: BHTRI = attlefield B Health and Trauma Research Institute; CCC = combat casualty care; CoE = enter C of Excellence; SAMMC = San Antonio Military Medical Center.
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From page 22... ...
He noted the value added in education and diversity -- for example, undergraduate research experiences that address security, privacy, and policy issues. He noted that TRUST has established a science base with multidisciplinary teams for building trustworthy systems and is a true academic, government, and industry undertaking and public-private partnership model, with integrative research areas and projects at the forefront of many emerging threats.
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U.S. Department of Homeland Security Sun Microsystems Physical Infrastructures Air Force Resource Laboratory RAPPORT • Embedded systems for SCADA ebay and control systems National Security Agency • Attacks and defenses for CSIT – Centre for Secure Information TRUST-REU TRUST Seminars sensor networks Technologies • Information privacy and iCAST – International Collaboration for security Advancing Technology Policy/Privacy and Science of Security AMRITA-TIFAC CORE in Cyber Security Cross Research Thrusts FIGURE 6 Overview of TRUST, a team for research in ubiquitous secure technology.
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From page 24... ...
These activities are congruent with what military expeditionary forces also experience. • Big Ideas @ Berkeley is a campus-wide annual competition that provides funding and encouragement to graduate and under graduate interdisciplinary teams with "Big Ideas." A spin-off includes a company that designs portable solar suitcases that power critical lighting and medical devices in areas without reli able electricity.
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From page 25... ...
. Illustrating performance metrics for infectious disease aerobiology over the past 5 years, he summarized extensive work on hundreds of discrete aerosol challenges, bioaerosol characterizations, and reagent delivery activities; a range of infectious agents or toxins; numerous challenges and experiments on animal exposures; dozens of bioaerosol characterization studies; and dozens of aerosol reagent drug delivery studies with animals.
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From page 26... ...
OPPORTUNITIES IN THE R&D LABORATORIES Robert Kaminski, Chief, Department of Diarrheal Disease Research, Bacterial Diseases Branch, Center for Infectious Disease Research at WRAIR, explained that WRAIR offers unique opportunities for scientists, such as science-focused product development, unique customers with unique needs, problems needing solutions outside the normal scope of U.S. public interests, unmatched global capabilities, and a diverse research portfolio.
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FIGURE 7 Combating the enteric disease threat across the phases of multi- omain operations. SOURCE: Robert Kaminski, Walter d Reed Army Institute of Research, presentation to the workshop.
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NOVEL ACADEMIC MODELS FOR TRANSLATIONAL RESEARCH Stephen Quake, professor of bio-engineering and applied physics at Stanford University and co-president of the Chan Zuckerberg Biohub, began with the Biohub organization initiation and noted receiving early inspiration from Don Ingber (the next speaker) regarding the researchinstitute concept.
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"Widget" Development Discovery Pre‐clinical Phase 1 Phase 2 Phase 3 Phase 4 Stage Development Academia Industry Department of Army Research Program FIGURE 8 Military, academia, and industry product development overlap. SOURCE: Robert Kaminski, Walter Reed Army Institute of Research, presentation to the workshop.
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Reprinted with permission from Springer Nature Customer Service Centre GmbH: Springer Nature, N Almanzar and the Tabula Muris onsortium, C A single-cell transcriptomic atlas characterizes ageing tissues in the mouse, Nature 583(7817)
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From page 31... ...
He closed with information relating to the COVID-19 pandemic and how his small and nimble organization could pivot and make contributions, such as in testing, developing a simple low-cost ventilator, understanding the cells in human lungs, and gaining insights into immunesystem responses. NEW INNOVATION MODEL THAT SPANS THE ACADEMIC-INDUSTRIAL-MILITARY INTERFACE Don Ingber, founding director, Wyss Institute for Biologically Inspired Engineering, Harvard University, began by indicating that engineering has transformed medicine over the past 30 years, and looking 30 years ahead, as boundaries between disciplines break down, biological principles can be leveraged to inspire future engineering opportunities.
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FIGURE 10 Wyss Institute platforms and initiatives. SOURCE: Don Ingber, Wyss Institute for Biologically Inspired Engineering, Harvard University, presentation to the workshop.
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Ingber noted many academic and translation successes, including 2,300 publications and 66 total licensing deals. His recommendations for Army research include the following: • Reducing formal requirements for technology development, • Increasing speed and flexibility in contracting, • Providing teams and leaders with more autonomy, • Creating funding sources independent of managed 5-year budgets, • Developing interdisciplinary collaborations within the research enterprise, • Integrating multidisciplinary approaches into the research enter prise, and • Focusing more on creativity and entrepreneurship rather than administration.
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