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An Assessment of the Material Measurement Laboratory at the National Institute of Standards and Technology Fiscal Year 2020 (2021) / Chapter Skim
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8 Biomolecular Measurement Division
Pages 49-55

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From page 49...
... They are as follows: Biomolecular Structure and Function; Mass Spectrometry Data Center; Applied Genetics; Bioprocess Measurement; and Bioanalytical Science. The BMD main areas of research are in forensic genetics and illicit drugs, clinical diagnostics using protein and nucleic acid markers, mass spectrometry reference data and library, and advanced biotherapeutics, which include the biomanufacturing and the engineering biology programs.
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From page 50...
... These include the following:  NIST Mass Spectrometry Data Center and libraries;  DNA forensics, which was recently leveraged for advancing and ensuring quality of nucleic acid-based testing for COVID-19;  Biomolecular reference materials for applications in clinical diagnostics, food safety, and biopharmaceutical development and manufacturing;  NIST's biomanufacturing program (as lead) , resulting in reference standards for monoclonal antibodies (e.g., NISTmAb RM 8671)
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From page 51...
... Concurrently, other accomplishments include methods for characterizing proteins from high order structure to biophysical characterization. Customer outreach through interlaboratory Measurement Comparisons, CRADAs (cooperative research and development agreements)
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From page 52...
... The division has worked to grow its expertise in protein drug manufacture as well as cell-based drug production strategies via its work on CHO cells and CAR T cells. Additionally, the division possesses abilities that are among the best in the world for standards design, production, and distribution including NIST mAb (monoclonal antibody)
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From page 53...
... 2 "The NIST NRC Postdoctoral Program supports a nationwide competitive postdoctoral program administered in cooperation with the National Academies/National Research Council (NRC) ." See NIST, "NIST NRC Postdoctoral Research Associateships Program," https://www.nist.gov/iaao/academic-affairs-office/nist-nrcpostdoctoral-research-associateships-program, accessed December 19, 2020.
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From page 54...
... Short industry-based learning experiences might further enhance the ability of NIST to understand and serve the needs of industry. Given that BMD is within the fourth largest biopharma zone in the United States, it has a geographical advantage in establishing unique educational experiences on which it might capitalize.
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From page 55...
... This includes a recent top 10 downloaded paper in the Journal of Forensic Science which was also a top 5 percent cited paper in Wiley Altimetrics. Other impressive numbers include 100 publications citing NIST mAb with over 200 collaborations and 1,000 units/year sold.
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Key Terms

  • mass spectrometry
  • reference data
  • measurement division
  • nist mab
  • data center

  • standard reference
  • protein sequencing
  • biomolecular structure
  • spectrometry data
  • particle sizing

  • applied genetics
  • measurement comparisons
  • measurement science
  • biological measurement
  • interlaboratory measurement

  • biomolecular measurement
  • main nist
  • permanent status
  • nrc postdoctoral
  • postdoctoral program

  • clinical diagnostics
  • finding resources
  • law enforcement
  • nist campus
  • nucleic acid

  • biophysical characterization
  • biological reference
  • measurement technology
  • nist mass
  • spectrometry reference


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