Critical Findings on COVID-19 Select Publications from the National Academies of Sciences, Engineering, and Medicine (2021) / Chapter Skim
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Rapid Expert Consultation Update on SARS-CoV-2 Surface Stability and Incubation for the COVID-19 Pandemic (March 27, 2020)
Rapid Expert Consultation Update on SARS-CoV-2 Surface Stability and Incubation for the COVID-19 Pandemic (March 27, 2020)
Pages 3-11
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From page 3... ...
Harvey Fineberg approved this document as chair of the Standing Committee on Emerging Infectious Diseases and 21st Century Health Threats. The following individuals served as reviewers: Kathryn Edwards, Vanderbilt University Medical Center; James LeDuc, University of Texas Medical Branch; and Linsey Marr, Virginia Tech.
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Such studies should also examine the effects of various treatments that might be used to disinfect PPE when they cannot be discarded after single use. Chad Roy from the Tulane University National Primate Research Center shared via telephone some preliminary results of dynamic aerosol stability experiments with SARS-CoV-2 conducted over the past several weeks at the Infectious Disease Aerobiology Core program at Tulane.
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From page 5... ...
However, the lack of detection of the virus in air samples does not necessarily contradict the finding of the virus on the air outlet fan in Patient C's room, which presumably deposited from 4 Personal communication, George Korch and Mike Hevey, National Biodefense Analysis and Countermeasures Center, March 24, 2020. 5 Personal communication, Vincent Munster, Rocky Mountain Laboratories, March 24, 2020.
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From page 6... ...
Of note, air collectors positioned more than 6 feet from each of two patients yielded positive samples, as did air samplers placed outside patient rooms in the hallways. Although the results are preliminary, it appears that some samples are positive for infectious virus, including an air 8 Jiang et al.
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The study observed that the negative pressure ventilation and high air exchange rate inside some locations were effective in minimizing airborne SARS-CoV-2. Additional findings suggest that virus-laden aerosol deposition may play a role in surface contamination and thus subsequent human infection.
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It is quite possible that virus from naturally infected humans when directly disseminated to the nearby environment has different survival properties than virus grown in TC media, even when the latter is purified and spiked into a relevant human body fluid such as saliva. However, environmental dissemination of clinically relevant human fluids spiked with TC-grown virus will be more predictive of real-world environmental survival than environmental dissemination of TC-grown virus in TC media.
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From page 9... ...
Before too many public health decisions are made on the basis of experimental or natural history studies using just one virus strain, some attention should be paid to the possibility of variation among different SARS-CoV-2 strains in their environmental survival properties. Different isolates from early and late in the pandemic, and from different geographic regions, should be studied and compared.
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From page 10... ...
Differences in incubation period findings among existing studies may relate to methodological differences, limited sample sizes, recall bias, or inadequate follow-up (potentially missing people who have longer incubation periods)
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From page 11... ...
Future studies related to incubation period and viral loads in asymptomatic patients may help to inform pressing questions related to, for example, the role of super spreaders and children in transmission. Respectfully, David A
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