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Appendix A: Study Methods
Pages 95-114

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From page 95... ... PUBLIC MEETING AGENDAS January 25 and 26, 2021 DAY 1: Monday, January 25, 2021 11:00 AM Welcome and Opening Remarks to Public Audience Hedvig "Hedi" Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair 11:15 Session 1: Statement of Work J. Read the entire page →
From page 96... ... Julian Preston, U.S. Environmental Protection Agency, Committee Vice Chair 1:30 Break 1:45 Session 3: Health and Medical Risk Characterization at NASA Erik Antonsen, Assistant Director for Human Systems Risk Management, NASA Johnson Space Center • Risk characterization • Comparison of radiation risks to health and medical risk • Radiation working group discussion points 2:10 Discussion with Committee Moderator: Hedi Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair 2:50 Closing Remarks Hedi Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair 3:00 Adjourn Day 1 DAY 2: Tuesday, January 26, 2021 11:00 AM Welcome and Opening Remarks to Public Audience Hedvig "Hedi" Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair Read the entire page →
From page 97... ... Environmental Protection Agency, Committee Vice Chair 1:00 Break 1:15 Session 6: Astronaut Office Perspective Serena Aunon-Chancellor, Astronaut • Crew perspective 1:30 Discussion with Committee Moderator: Hedi Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair 2:00 Session 7: NASA Proposed Standards and Summary David Francisco, Technical Fellow for Human Spaceflight Standards, NASA HQ J. Read the entire page →
From page 98... ... D Polk, Chief Health and Medical Officer, NASA David Francisco, Technical Fellow for Human Spaceflight Standards, NASA HQ Edward Semones, Space Radiation Analysis Group, NASA Johnson Space Center 12:30 Discussion with Committee Moderator: Hedi Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair 1:30 Adjourn Open Session Wednesday, April 14, 2021 1:00 PM Convening Public Webinar and Welcome Hedvig "Hedi" Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair Gayle Woloschak, Northwestern University, Committee Member Read the entire page →
From page 99... ... Motivation, Agenda, and Future Plans Werner Rühm, Helmholtz Zentrum München, Germany, TG115 Chair 2:20 Overview of International Space Agencies Assessment of Dose and Risk for Astronauts Marco Durante, GSI Helmholtz Center, Germany, TG115 Member 1:40 Discussion with Committee and ICRP's TG115 Members Gayle Woloschak, Northwestern University, Committee Member ICRP discussants include • Chunsheng Li, Health Canada, Canada; TG115 member • Ulrich Schraube, European Space Agency, Germany; TG115 member • Vyacheslav Shursahkov, Russian Space Agency, Russian Federation; TG115 member • Leena Tomi, Canadian Space Agency, Canada; TG115 member • Alexander Ulanowski, International Atomic Energy Agency, Austria; TG115 member • Jing Chen, Health Canada, Canada • Chris Clement, ICRP Scientific Secretary • Mikhail Dobynde, Institute of Biomedical Problems, Russian Academy of Sciences • Samy El-Jaby, Canadian Nuclear Laboratory, Canada • Mark Shavers, International Systems Maturation Team, United States • Guangming Zhou, Suzhou University, China 2:30 Adjourn Open Session Read the entire page →
From page 100... ... • Background Information, January 21, 2021, White Paper2 NASA provided updated background information for the committee, including the specific factors NASA is considering in modifying the standard, why NASA is considering a change to the standard, and the proposed update to the NASA Space Permissible Exposure Limit for Spaceflight Radiation Exposure Standard, as well as background on the space radiation environment, international partner standards, and NASA standards. • Proposed Standard Overview, Alternate Options, and Clarifications, February 2021, Revision A2 NASA provided clarifying material and an updated white paper based on questions and comments from the committee at the public meeting on January 25 and 26, 2021. Read the entire page →
From page 101... ... • Ensemble Methodologies for Astronaut Cancer Risk Assessment in the Face of Large Uncertainties, October 20201,4 Provides an overview of a new approach to NASA space radia tion risk modeling that has successfully extended the current NASA probabilistic cancer risk model to an ensemble framework able to consider submodel parameter uncertainty (e.g., uncertainty in a radiation quality parameter) as well as model-form uncertainty as sociated with differing theoretical or empirical formalisms (e.g., combined dose-rate and radiation quality effects) Read the entire page →
From page 102... ... • Office of the Chief Health and Medical Officer Human Spaceflight Standards Newsletter, March 20212 March 2021 newsletter to all astronauts that provides updates on human spaceflight standards. 5 See https://www.nasa.gov/sites/default/files/atoms/files/radiation_protection_technical_ brief_ochmo_021420.pdf (accessed April 16, 2021) Read the entire page →
From page 103... ... APPENDIX A 103 Table A-1 starts on the next page. Read the entire page →
From page 104... ... Low-dose Occupational 15-country study: Cardis F/M: 0.0194 Sv (average exposures et al., 20075 – nuclear cumulative recorded whole industry workers body external dose for the whole cohort) UK NRRW: Muirhead F/M: 0.0249 Sv (mean et al., 20096 – radiation lifetime recorded whole workers body external dose for the pooled cohort) Read the entire page →
From page 105... ... for Lung Cancera,b,c F: 50,924 F: 657 F: 1.10 (0.68, 1.60) Read the entire page →
From page 106... ... plutonium production Whole cohort: 0.115 facility F: 0.165 M: 0.093 External dose among exposed: Whole cohort: 0.397 F: 0.335 M: 0.418 Fernald: Silver et al., Mean cumulative dose to 20139 – uranium lung (μGy) processing workers Females Caucasian Hourly: 67.9 Salaried: 296 Females non-Caucasian Hourly: 34.5 Salaried: 154 Males Caucasian Hourly: 1,552 Salaried: 388 Males non-Caucasian Hourly: 965 Salaried: 138 Mound Nuclear Facility: F/M: 0.1 Sv (full cohort Boice et al., 201410 – combined dose to the lung workers in the nuclear from internal and external weapons production radiation) Read the entire page →
From page 107... ... for Lung Cancera,b,c Full cohort: Full cohort: Plutonium lung dose: F: 3,703 F: 40 F, age 60: 24 (11, 56) Read the entire page →
From page 108... ... workers M: 0.0275 Sv (mean lifetime recorded whole-body external dose for the pooled cohort) INWORKS: Richardson Organ-specific cumulative et al., 201813 – nuclear external dose: workers F: 0.0048 M: 0.0228 Industrial radiographers: External radiation and Boice et al., 201914 iridium-192 and cobalt-60 dose: F: 0.002 M: 0.012 Mound: Boice et al., Full cohort combined dose 201914 – workers in to the lung from internal the nuclear weapons and external radiation: production facility F: 0.0249 M: 0.1129 Nuclear power plant: Full cohort combined dose Boice et al., 201914 to the lung from internal and external radiation: F: 0.0179 M: 0.0413 NPP + IR: Boice et al., Full cohort combined dose 201914 to the lung from internal and external radiation: F: 0.0061 M: 0.0278 U.S. Read the entire page →
From page 109... ... for Lung Cancera,b,c F: 16,437 F/M: 3,058 ERR/Sv M: 150,566 F/M: 0.028 (–0.44, 0.63) (lung, trachea, bronchus) Read the entire page →
From page 110... ... Canadian TB fluoroscopy: Total lung tissue dose among Boice et al., 201914 exposed: F: 1.072 M: 1.038 Abbreviations: CI = confidence interval; ERR/Gy = excess relative risk per gray; ERR/Sv = excess relative risk per sievert; F = female; F/M = combined estimate for females and males; Gy = gray; IR = industrial radiographer; LC = lung cancer; M = male; NPP = nuclear power plant; RR/100 mGy = relative risk per 100 milligray; SMR = standardized mortality ratio; Sv = sievert; TB = tuberculosis. a In this table, the committee chose to present the results as they appeared in original publications. Read the entire page →
From page 111... ... for Lung Cancera,b,c F: 6,513 Exposed: Exposed: M: 6,872 F: 19 F: SMR = 0.8 M: 50 M: SMR = 0.8 Unexposed: Unexposed: F: 22 F: SMR = 1.0 M: 104 M: SMR = 1.4 F: 31,917 F: 266 ERR/Sv: M: 32,255 M: 912 F: –0.08 (–0.10, 0.07) Read the entire page →
From page 112... ... 2009. Mortality and cancer incidence following occupational radiation exposure: Third analysis of the National Registry for Radiation Workers. Read the entire page →
From page 113... ... 1995. Lung cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with lung cancer mortality in the atomic bomb survivors study. Read the entire page →

From page 95...

... PUBLIC MEETING AGENDAS January 25 and 26, 2021 DAY 1: Monday, January 25, 2021 11:00 AM Welcome and Opening Remarks to Public Audience Hedvig "Hedi" Hricak, Memorial Sloan Kettering Cancer Center, Committee Chair 11:15 Session 1: Statement of Work J.

Appendix A: Study Methods Pages 95-114

Appendix A: Study Methods
Pages 95-114