Scanning for New Evidence on Riboflavin to Support a Dietary Reference Intake Review (2021) / Chapter Skim
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Abstract
Abstract
Pages 1-6
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Department of Health and Human Services, Food and Drug Administration, Center for Food Safety and Applied Nutrition requested that the National Academies carry out an evidence scan on new and emerging evidence on riboflavin that could be used to support a DRI review. A committee was convened to develop a framework for scanning the peer-reviewed published literature, based on the generic analytic framework for DRIs, to assess the relation of nutrient intake to health outcomes (adequacy, risk of chronic disease, and toxicity)
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If they agreed that an article was eligible, data on study characteristics, population characteristics, intake assessment methods, riboflavin status, clinical outcomes, and chronic disease outcomes were extracted using a similar verification process.
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The dotted lines represent associations with validated surrogate outcomes and biomarkers. The arrows represent the direction of an association.
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The committee identified as an important lesson learned an understanding and appreciation of the critical nature of the iterative process. This became apparent at all levels of the screening.
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In the absence of a validated biomarker or surrogate marker and/or uncertainty about dietary intake estimates, the committee perceived a need to identify a means to consider new and emerging methodologies to estimate riboflavin intake. This could include nontraditional methods to obtain estimates of nutrient status, such as -omics technology to detect riboflavin status in relevant genotypes.
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6 SCANNING FOR NEW EVIDENCE ON RIBOFLAVIN achieve its purpose but still specific enough to accurately reflect the current status of the evidence on riboflavin needed to support a DRI review.
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