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2 Methodological Approach to Evidence Scanning
Pages 11-18

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From page 11...
... and health outcomes, including chronic disease risk, that could inform a future DRI review. The committee began by developing key questions, to serve as an organizational tool for identifying search terms, and prespecified inclusion and exclusion criteria, to inform eligibility of the search results for subsequent data extraction and tabulation.
From page 12...
... Search Strategy The committee developed a search strategy that included a search syntax containing specific text words (i.e., natural language terms) and controlled vocabulary terms (medical subject headings [MeSH]
From page 13...
... o Pregnant and lactating women • By riboflavin fortificationb status of country • By chronic disease status o Hypertension Exclude: • Studies in which ≥20% of individuals had existing chronic diseasesc,d such as o Diabetes o Cancer o Cardiometabolic disorders o Chronic kidney disease o Malabsorption (including any disorder that causes malabsorption from the gastrointestinal tract) Interventions/ Riboflavin intake -- amount,e frequency, duration Exposures Indicators/biomarkers, such as • Erythrocyte glutathione reductase activity/activation coefficient (EGRAC)
From page 14...
... • Other relevant outcomes Toxicity outcomes • Neuropathies • Adverse event reports related to riboflavin Chronic disease risk outcomes • Preeclampsia • Hypertension (surrogate is blood pressure) • Cervical cancer • Colorectal cancer • Other cancers • Cardiovascular disease • Neurological disorders • Other related chronic diseases Study Designs • Randomized controlled trials (crossover, parallel, factorial)
From page 15...
... In the comprehensive systematic review process, selecting and assessing reported data are prespecified and informed by the analytic framework. In contrast, narrative reviews do not have a defined structure for identifying and selecting relevant studies, which may limit data availability and potentially influence data interpretation.
From page 16...
... Following the internal assessment, trained staff performed an initial title and abstract screening of each record retrieved using the prespecified criteria in Table 2-1. Next, pairs of committee members independently screened each title and abstract that staff deemed potentially eligible.
From page 17...
... 2009. Opportunities and challenges in conducting systematic reviews to support the development of nutrient reference values: Vitamin A as an example.


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