Leveraging Advances in Modern Science to Revitalize Low-Dose Radiation Research in the United States (2022) / Chapter Skim
Currently Skimming:
Pages 1-9
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 1... ...
government decisions related to the future of nuclear power and clean energy policies, continuing efforts to assess the full range of radiogenic health outcomes of legacy exposures to fallout from nuclear weapons production, testing, and waste sites, management of nuclear waste, and plans for responding to radiological threats. These concerns also raise questions as to whether the public and workers are adequately protected from current environmental and occupational radiation exposures and from potential new sources of exposure such as rare earth element and lithium mining to support green energy and long-term energy policies in the United States.
|
From page 2... ...
The National Academies appointed an expert committee to define the essential components and to set priorities to guide research for a multidisciplinary coordinated low-dose radiation program that is developed neutrally in terms of the impact of the research on assessment of radiation health risk and consequently its potential impact on radiation protection policy and practice in the United States. The proposed program as outlined in this report involves the broad research enterprise and goes beyond the resources of any one federal agency.
|
From page 3... ...
. Finding 1: A coordinated multidisciplinary low-dose radiation research program in the United States can improve understanding of adverse human health effects from exposures to radiation at doses and dose rates of relevance to the U.S.
|
From page 4... ...
Finding 3: The committee is unable to quantify the low-dose radiation program's economic impacts because comprehensive estimates of over all costs to comply with current radiation standards are unavailable. Additionally, any changes to the current estimates will depend on new information on adverse health effects that will be generated by the low dose radiation research program.
|
From page 5... ...
A revitalized low-dose radiation research program can likewise leverage and further develop these capabilities to enable scientific innovation and breakthroughs in radiation biology and epidemiology.
|
From page 6... ...
Finding 7: Significant investments over a sustained period spanning sev eral decades are necessary to develop and maintain a multidisciplinary low-dose radiation research program in the United States that lever ages existing and developing research infrastructure that will achieve the goals outlined in Finding 1. The committee's best estimate is that the investments required during the first 10–15 years of the program are at the level of $100 million annually and periodic reassessments are required as large epidemiological studies and necessary research infrastructures are established.
|
From page 7... ...
Inadequate funding for the program will lead to continued scientific and policy debates about risks of low doses of radiation to the possible detriment of adequate protection of patients, workers, and members of the public from the adverse effects of radiation. ELEMENTS OF A SUCCESSFUL LOW-DOSE RADIATION RESEARCH PROGRAM The following two findings and one recommendation address the essential elements of a successful low-dose radiation research program (see Chapter 6)
|
From page 8... ...
I2 Harmonized databases to support biological and epidemiological studies. I3 Dosimetry for low-dose and low-dose-rate exposures.
|
From page 9... ...
Establish radiation dose-response curves for molecular and cellular E1–E3; I1–I4 endpoints and for associated early- and late-stage diseases at doses below 10 mGy and dose rates below 5 mGy/h. Assess the impact of genetic makeup, epigenomic status, DNA repair E1–E3; I1–I4 efficacy, comorbidities, exposure history to radiation and other agents, lifestyle factors, and immune status on low-dose and low-dose-rate radiation-induced adverse health effects and associated cellular and molecular response endpoints.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.