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Leveraging Advances in Modern Science to Revitalize Low-Dose Radiation Research in the United States (2022) / Chapter Skim
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Appendix D: Projects Designated by the Department of Energy as "Low-Dose Radiation Projects" Carried Out at National Laboratories (20162021)
Pages 289-294

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From page 289...
... Appendix D Projects Designated by the Department of Energy as "Low-Dose Radiation Projects" Carried Out at National Laboratories (2016–2021)
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From page 290...
... ; Oregon Health & Science University (direct sponsor) LBNL 2014–2019 $1,583,882 NASA LBNL 2015–2016 $199,929 NASA LBNL 2015–2017 $200,474 NASA LBNL 2015–2019 $297,416 NASA (prime sponsor)
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From page 291...
... AI-driven data integration and multiscale modeling approaches to low-dose radiation effects understanding Leaf microbiome as a monitoring tool for nuclear activities Understanding the impact of space radiation on human gut microbiome Human Exposure of Radiation using Organ Systems (HEROS) Low-dose scientific focus area The identification of specific genetic and molecular profiles induced by low-dose radiation that lead to loss of mammary tissue architecture and tumor progression Harderian gland tumorigenesis low-dose, low-dose-rate, and LET response Comparative analysis of charged particle–induced autosomal mutagenesis in murine tissue and cells Space radiation risk assessment project Novel interactions of DNA repair processes in replication fork maintenance Effects of low-dose radiation on long-term synaptic plasticity and neurogenesis in normal and Alzheimer's disease transgenic mice Impact of age, genetic variants, and high-LET track structure on mammary cancer risk estimates The relation between mutagenesis and genomic instability after particle exposure in vivo Molecular characterization of choroid plexus and hippocampal damage and degenerative CNS risks from space radiation Integrating LBNL DSB clustering model with NASA modeling tool to predict cell death and chromosomal aberration in human cells exposed to galactic cosmic ray Space adaptation effects on immune system impacts reproductive function and mammary gland development across generations Measurement of and countermeasures against, degenerative heart disease from space radiation GCR simulator studies with human and mouse models Blood-based multiscale model for cancer risk from galactic cosmic ray in genetically diverse populations Simulation of GCR-induced Harderian gland and lung tumorigenesis Defining the relationship between simulated weightlessness and space radiation on cardiovascular disease Variation in CNS damage signaling and blood sentinels of neuropathology after exposure to space radiation Molecular characterization of CNS tissue damage and neurocognitive risks from space radiation continued
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From page 292...
... NOTE: ANL = Argonne National Laboratory; BER = DOE-Biological and Environmental Research; BNL = Brookhaven National Laboratory; CNS = central nervous system; DOE = Department of Energy; DSB = double strand break; DTRA = Defense Threat Reduction Agency; GCR = galactic cosmic ray; JGI = Joint Genome Institute; LANL = Los Alamos National Laboratory; LBNL = Lawrence Berkeley National Laboratory; LDRD = Laboratory Directed
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From page 293...
... Dynamics of Microbiomes in Space (DynaMoS) Research and Development; LET = linear energy transfer; LLNL = Lawrence Livermore National Laboratory; MIPG = metaiodobenzylguanidine; NASA = National Aeronautics and Space Administration; NCI = National Cancer Institute; NIH = National Institutes of Health; NNSA = National Nuclear Security Administration; ORNL = Oak Ridge National Laboratory; PPNL = Pacific Northwest National Laboratory; UC = University of California.
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Key Terms

  • space radiation
  • galactic cosmic
  • prime sponsor
  • direct sponsor
  • cosmic ray

  • ldrd ornl
  • multiscale modeling
  • ber ornl
  • modeling approaches
  • data integration

  • harderian gland
  • nih lbnl
  • ldrd llnl
  • cancer risk
  • lung tumorigenesis

  • radiation effects
  • effects understanding
  • molecular characterization
  • genomic instability
  • gland development

  • diverse populations
  • populations simulation
  • degenerative heart
  • modeling tool
  • mammary gland

  • security administration
  • track structure
  • reduction agency
  • murine tissue
  • tumor progression


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