Leveraging Advances in Modern Science to Revitalize Low-Dose Radiation Research in the United States (2022) / Chapter Skim
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Appendix E: Unedited Responses from Radiation Facilities
Appendix E: Unedited Responses from Radiation Facilities
Pages 295-318
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Appendix E Unedited Responses from Radiation Facilities 295
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Please provide a brief description of your radiation sources and facilities including location, type of source, first year of operation and expected date for removal/decommissioning, and types of activities these sources and facilities support (e.g., research, radiobiology experiments, radioisotope production, other)
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All radiation facilities at AFRRI are flexible to provide a variety of dose rates and total accumulated doses to experiments through manipulation of exposure time, distance, shielding, and strength of radiation source. The TRIGA reactor is unique in the ability to provide mixed-field (gamma and neutron)
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Please describe and if possible provide publications that describe use of your radiation facilities to facilitate radiation research. Irradiation facilities are configurable for live animals, cell cultures and tissues, and other inanimate projects/subjects.
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Biological labs are located throughout the building for in-house Principal Investigators AFRRI appreciates the great opportunity that the National Academy of Science Committee on Developing a Long-Term Strategy for Low-Dose Radiation Research in the United States is providing by inviting us to participate in the information gathering meeting last month and requesting additional information on radiation facilities. Should you need any further technical information, please contact Lieutenant Colonel Lu Makinde at (301)
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at various heights from the sources and irradiate at low dose rate for days. From a position of 56 cm to 180 cm above the sources, thirty-five stacks of T75 tissue culture flasks can be placed for different dose rates.
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A higher dose rate of 0.41 cGy/min was used in a radiation countermeasure study done by Cleveland BioLabs in the facility. Low dose rate neutron vivarium.
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PMID: 16953663. MRB 12 Low dose rate tissue culture Amdur, R.J.
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Radiat Res 191..
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Design and dosimetry of a facility to study health effects following exposures to fission neutrons at low dose rates for long durations. Int J Radiat Biol.
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New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation. eNeuro.
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Proton Treatment and Research Center Radiation Biology Facilities and Logistic Support Report Marcelo E Vazquez M.D., Ph.D.
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. The facility can provide very low dose rates settings if a non-clinical setup is arranged.
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Energies (MeV) 50 to 250 50 to 250 2 to 22 Dose Rates (cGy/min)
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. Irradiation facilities can provide anesthesia and monitoring capabilities for in vivo studies.
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Scientists can access the LLURM radiation sources via collaborative agreement with the LLURM Research and Development team. Collaborative agreements and beam utilization are coordinated by Dr.
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Simulated Microgravity and Low-Dose/Low-Dose-Rate Radiation Induces Oxidative Damage in the Mouse Brain. Radiat Res.
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Please provide a brief description of your radiation sources and facilities including location, type of source, first year of operation and expected date for removal/decommissioning, and types of activities these sources and facilities support (e.g., research, radiobiology experiments, radioisotope production, other)
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For radiobiology experiments, are your facilities mostly used for exposure of cells, tissues, or animals? Please describe and if possible provide publications that describe use of your radiation facilities to facilitate radiation research.
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Please see: https://www.bnl.gov/techtransfer/partnerships.php 5. Is there available adjacent infrastructure that facilitates radiation research such as tissue culture and animal facilities?
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In particular, a number of the RARAF beams have been specifically designed to facilitate studies of radiobiological effects at very low doses. For example, the RARAF microbeam beamline is designed to allow delivery of the ultimate low dose of exactly one particle to targeted cells, and has been extensively used to facilitate studies of the effects of domestic radon exposures – the largest single source of background radiation exposure.
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To mimic prompt exposures from an IND, we have adapted a clinical accelerator to deliver ultra high dose rates high dose rates. Using 9 MeV electrons, samples can be irradiated inside the Clinac head at average dose rates of up to 600 Gy/sec (3 Gy per 0.5 µsec pulse, 180 pulses per sec)
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2022 >150 keV/µm (Li+3, B+5, C+6) Decommissioning Not planned Not planned Not planned Not planned Activities radiobiology radiobiology radiobiology radiobiology experiments experiments experiments experiments Dose range (max)
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Wang, Q., et al., DNA damage response in peripheral mouse blood leukocytes in vivo after variable, low-dose rate exposure. Radiation and Environmental Biophysics, 2020.
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