Memorial Tributes Volume 24 (2022) / Chapter Skim
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CHRISTODOULOS A. FLOUDAS
CHRISTODOULOS A. FLOUDAS
Pages 104-111
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From page 105... ...
The main paper of his PhD work on automatic synthesis of heat exchanger networks was based on a novel nonlinear programming model and established him as an important contributor in the area.1 The work enabled network designs to be obtained by optimizing superstructures that contained all the alternative topologies Floudas CA, Ciric AR, Grossmann IE.
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From page 106... ...
This relaxation is obtained by replacing all nonconvex terms of special structure -- bilinear, trilinear, fractional, fractional trilinear, univariate concave -- with customized tight convex lower bounding functions and by selecting some suitable value of α to generate valid convex underestimators for nonconvex terms of generic structure. A crucial step was in the use of interval arithmetic on the Hessian matrix or the characteristic polynomial of the function being investigated.
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From page 107... ...
The major algorithmic components of GloMIQO involved reformulating user input, detecting special structure including convexity and edge-concavity, generating tight convex relaxations, partitioning the search space, bounding the variables, and finding good feasible solutions. GloMIQO was extensively tested on 400 test problems of varying size and structure, including general nonconvex terms.
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From page 108... ...
His work has had industrial impact as it has been applied by companies such as Shell, Aspen Technology, BASF, and Atofina Chemicals. In computational biology Chris introduced a first-principles structure prediction method, ASTRO-FOLD, for helical and beta-sheet topology; invented new methods for NMR structure refinement based on atomistic modeling; and pioneered de novo design strategies for peptides and proteins.
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From page 109... ...
. Chris's legacies include the outstanding PhD students and postdocs he advised and mentored who have taken academic positions; they include Claire Adjiman, Peter DiMaggio, Chrysanthos Gounaris, Faruque Hasan, Marianthi Ierapetritou, Nina Lin, Costas Maranas, and Ruth Misener.
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From page 110... ...
The only consolation is to know that his legacy will continue through his students and that his work will inspire new generations of researchers in optimization and process systems. We offer our deepest sympathy to his wife Fotini and daughter Ismini.
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