Understanding the Role of the Immune System in Improving Tissue Regeneration Proceedings of a Workshop (2022) / Chapter Skim
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Appendix B: Speaker Biographical Sketches
Appendix B: Speaker Biographical Sketches
Pages 151-162
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From page 151... ...
Her laboratory discovered that transient exposure to prostaglandin E2 rejuvenates muscle stem cell function long term, enhancing muscle repair. She identified a novel hallmark of aging, the prostaglandin degrading enzyme, 15-PGDH, and showed that its inhibition augments aged muscle mass and strength.
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From page 152... ...
Dr. Elisseeff is the director of the Translational Tissue Engineering Center, where she and her team of scientists are engaged in engineering technologies to repair lost tissues and are using biomaterials to develop a synthetic cornea.
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From page 153... ...
in 2009. In 2009 she also founded Aegeria Soft Tissue and Tissue Repair, startups focused on soft tissue regeneration and wound healing.
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From page 154... ...
Dr. Kirkland's research is on the contribution of fundamental aging processes, particularly cellular senescence, to age-related and chronic diseases and development of agents and strategies for targeting fundamental aging mechanisms to treat age- and chronic disease–related conditions.
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From page 155... ...
She is also a member of several advisory boards and has been responsible for the organization of several national and international scientific meetings, and also served on many program committees. She is the recipient of several awards including the Knut & Alice Wallenberg Foundation award for young female researchers, the Swedish Medical Society award for young scientists, and the Tobias Foundation Prize for the excellent studies of the immunological properties of mesenchymal stem cells and their use in mesenchymal stem cell therapy, awarded by the Royal Swedish Academy of Science.
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From page 156... ...
Ongoing research efforts of the Moore Lab seek to understand how immune cells can be leveraged to enhance tissue regeneration, develop materials capable of directing immune cells towards desired clinical outcomes, and create in vitro tissue models to profile immune cell–blood vessel interactions in clinically relevant disease settings. Her lab is especially interested in applications for the autoimmune disorder lupus, which disproportionately affects Black women.
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From page 157... ...
Michel Sadelain, M.D., Ph.D., is the founding director of the Center for Cell Engineering and head of the Gene Transfer and Gene Expression Laboratory at Memorial Sloan Kettering Cancer Center, where he holds the Stephen and Barbara Friedman Chair. He is also a member of the departments of Medicine and Pediatrics at Memorial Hospital and the molecular pharmacology and chemistry program of the Sloan Kettering Institute.
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From page 158... ...
Work by Dr. Sonja Schrepfer is at the forefront of stem immunobiology and paves the way for treatment of a wide range of diseases -- from supporting functional recovery of failing myocardium to the derivation of other cell types to treat diabetes, blindness, cancer, lung, neurodegenerative, and related diseases.
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From page 159... ...
following hematopoietic cell transplantation (HCT) by allowing GVH-reactive T cells to expand while preventing migration to the epithelial GVHD target tissues.
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From page 160... ...
Prior to that, he played key scientific roles at Amgen, the Center for Cell Control (an NIH Nanomedicine Development Center) , and the Broad Stem Cell Research Center, developing novel methods to control pluripotency, to modulate stem cell fate including hematopoiesis, and to better understand cellular signaling pathways associated with cancer.
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From page 161... ...
Dr. Wynn has been included on the Thomson Reuters list of Highly Cited Researchers due to his important contributions to understanding the role of cytokines and growth factors in the progression and resolution of chronic inflammation, tissue regeneration, and fibrosis.
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