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Pages 461-484

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From page 461...
... Rider, M.D., Acting Head, Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH 3:00 – 3:25 John O'Shea, Ph.D., Scientific Director and Director of Intramural Research Program, NIAMS, NIH 3:25 – 3:40 Break NIH Extramural Research for Autoimmune Diseases Across ICs 3:40 – 4:05 Lisa Spain, Ph.D., Program Director, Division of Diabetes, Endocrinology, and Metabolic Diseases, NIDDK, NIH 4:05 – 4:30 Michael C Humble, Ph.D., Program Administrator, Genes, Environment and Health Branch, Division of Extramural Research and Training, NIEHS, NIH 4:30 – 4:55 Nishadi Rajapakse, Ph.D., M.H.S., Program Director, Transdisciplinary Collaborative Centers on Precision Medicine, Centers of Excellence on Environmental Health Disparities, Division of Scientific Programs, NIMHD, NIH 4:55 – 5:30 Discussion 5:30 Adjourn
From page 462...
... James, M.D, Ph.D, Vice President of Clinical Affairs, Member & Chair, Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation; Associate Vice Provost for Clinical and Translational Science, Professor of Medicine, Professor of Pathology, Oklahoma University Health Sciences Center 1:30 -1:55 Advances and Opportunities in Dermatological Autoimmune Diseases Victoria P Werth, M.D., Professor of Dermatology at the Hospital of the University of Pennsylvania and the Veteran's Administration (V.A.)
From page 463...
... . Again, however, children were not included, and Sjögren's disease commonly co-occurs with other autoimmune diseases, so while this prevalence may reflect primary Sjögren's disease in adults, it fails to capture the full extent of individuals in the United States with Sjögren's disease.
From page 464...
... SYSTEMIC LUPUS ERYTHEMATOSUS Epidemiology Overview A recent meta-analysis based on data from a Centers for Disease Control and Prevention (CDC) network of four national lupus registries estimated overall SLE incidence in the United States as 5.1 per 100,000 person years for 2002 to 2009 (Izmirly et al., 2021a)
From page 465...
... , the incidence and prevalence rates of SLE were around nine times higher in women than in men. When examining only women, incidence and prevalence rates were highest for non-Hispanic Black women, and showed a marked increase in the 20–59 age groups (Figure D-2)
From page 466...
... B Incidence of Systemic Lupus Erythematosus in Women in Fulton and DelKalb Counties, Georgia, 2002–2004 by age and race.
From page 467...
... Dall'Era et al., 2017. FIGURE D-1 Continued Although the rates of some autoimmune diseases are lower in children than adults, these diseases have a significant impact on the children and their families.
From page 468...
... 468 ENHANCING NIH RESEARCH ON AUTOIMMUNE DISEASE A B FIGURE D-2  Incidence and prevalence of SLE in women residents of New York County (Manhattan) , showing age and race and ethnicity.
From page 469...
... . Although lupus nephritis and NPSLE typically occur early in the disease course, they can occur years after the onset of disease in some patients.
From page 470...
... . RHEUMATOID ARTHRITIS Epidemiology Overview Rheumatoid arthritis is one of the most common autoimmune diseases, affecting an estimated 2.4 million adults in the United States
From page 471...
... . With respect to health outcomes and disability measures among people with rheumatoid arthritis, studies have observed higher disease activity and lower rates of remission among Black and Hispanic populations compared with White populations (Barton et al., 2011; Greenberg et al., 2013)
From page 472...
... . INFLAMMATORY BOWEL DISEASE Epidemiology Overview Ulcerative colitis and Crohn's disease have emerged as global diseases in the 21st century (Ananthakrishnan et al., 2020)
From page 473...
... There is an approximately 4-fold increased risk of ulcerative colitis in the children of mothers or fathers with ulcerative colitis and an almost 8-fold increased risk of Crohn's disease in the children of mothers or fathers with Crohn's disease (Agrawal et al., 2021; Moller et al., 2015) , as well as similar patterns regarding which parts of the intestinal system the disease affects.
From page 474...
... . Sex, Age, Racial and Ethnic Disparities Celiac disease is 1.5 times more common in females than in males, and approximately 2 times more common in children than in adults (Singh et al., 2018)
From page 475...
... . For adult-onset multiple sclerosis, the mean age at clinical diagnosis is 30 years (Mayo Clinic, 2021)
From page 476...
... . There is a dearth of data on delay in diagnosis in racial and ethnic minority populations, however, with several studies suggesting that delays result from a lack of access to a multiple sclerosis specialist and to perceptions among physicians that the disease is more common in White populations (Stuifbergen et al., 2021)
From page 477...
... . A large cohort study in the Netherlands examined thyroid medication use and thyroid hormone levels to classify overt and subclinical thyroid diseases.
From page 478...
... Autoimmune Diseases 2015:298506. https://doi.org/10.1155/2015/298506.
From page 479...
... 2017. Rural and urban residence during early life is associated with risk of inflammatory bowel disease: A population-based inception and birth cohort study.
From page 480...
... 2003. The epidemiology of autoimmune diseases.
From page 481...
... https://www.fda.gov/ consumers/minority-health-and-health-equity/clinical-trial-diversity (accessed March 16, 2022)
From page 482...
... 2012. Prevalence, incidence and demographics of systemic lupus erythematosus and lupus nephritis among Medicaid-enrolled U.S.
From page 483...
... 2014. National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000–2009.
From page 484...
... 2015. Familial risk of inflammatory bowel disease: A population-based cohort study 1977-2011.


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