Enhancing NIH Research on Autoimmune Disease (2022) / Chapter Skim
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and RePORTER. Patent data was linked to 8,470 autoimmune disease grants of interest using a matching.
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of autoimmune disease research. The goal of this paper is to provide insight into the most popular research topics associated with 8,470 NIH autoimmune disease research grant abstracts using latent dirichlet allocation (LDA)
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. Given a set of 8,470 NIH research grant abstracts related to autoimmune diseases that were funded between 2008 and 2020, topic modeling using LDA was implemented to discern which topics are prevalent within the abstracts.
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Cancer, multiple sclerosis, cardiovascular, psoriasis, lung disease, and rheumatoid arthritis are also consistent over time but not as popular as diabetes. It is difficult to explain the spikes in popularity in administrative topics.
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514 FIGURE H-1 Coherence scores for k number of topics.
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FIGURE H-2 Top 10 words per topic.
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23 Genetics 24 Quality of Life 25 Inflammatory Bowel Disease 26 Multiple Sclerosis 27 Pathogenesis 28 Diagnostic 29 Virus (infectious etiology) 30 Imaging SOURCE: NIH, 2021.
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FIGURE H- 3 LDA-generated topics for NIH autoimmune disease grants, FY 2008–2020: Immune response related topics. NOTES: FY, fiscal year; LDA, latent dirichlet allocation.
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518 FIGURE H-4 LDA-generated topics for NIH autoimmune disease grants, FY 2008–2020: Clinical topics. NOTES: FY, fiscal year; LDA, latent dirichlet allocation.
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FIGURE H-5 LDA-generated topics for NIH autoimmune disease grants, FY 2008–2020: Disease focused topics. NOTES: FY, fiscal year; LDA, latent dirichlet allocation.
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520 FIGURE H-6 LDA-generated topics for NIH autoimmune disease grants, FY 2008–2020: Administrative topics. NOTES: FY, fiscal year; LDA, latent dirichlet allocation.
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