Report of the Committee on Proposal Evaluation for Allocation of Supercomputing Time for the Study of Molecular Dynamics Thirteenth Round (2022) / Chapter Skim
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BIOGRAPHICAL SKETCHES OF COMMITTEE MEMBERS
BIOGRAPHICAL SKETCHES OF COMMITTEE MEMBERS
Pages 13-22
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From page 13... ...
A molecular and structural understanding of these GPCR signaling pathways will have a broad impact on understanding of cellular signaling and on drug discovery efforts targeting GPCRs, as they are targets for ~50% of the drugs in the clinic. Research in the Abrol Research Lab is also combining computational biophysics and structural bioinformatics methods to gain mechanistic insights into the evolutionary and pathological biochemistry of membrane protein folding and functions.
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His research program focuses on the development of theoretical and computational methods and application of these methods to advance understanding of biophysical, biochemical, and biomedical problems. Key problems currently under study in Chen's lab include intrinsically disordered proteins in biology and diseases, protein amyloid formation in neurogenerative diseases, self-assembling peptide vesicles for drug delivery, and transmembrane ion channel protein activation and regulation.
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His laboratory strives to discover therapies for unmet health challenges through a detailed study of biomolecular dynamics and interactions using molecular simulations and experiments. Among his major contributions is the finding that oncogenic Ras proteins adopt multiple membrane orientations whose relative population is modulated by the bound nucleotide, mutation, or lipid composition.
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His lab carries out molecular dynamics simulations aimed primarily at understanding the composition, construction, and function of the Gram-negative bacterial cell envelope. Gumbart has served on previous molecular dynamics review committees convened by the National Academies.
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Okafor received the Burroughs Wellcome Fund Career award at the scientific interface, the Ford Foundation postdoctoral fellowship (declined) , and the National Science Foundation CAREER Award.
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in physical chemistry from the University of Missouri in 1999, he began investigating enzyme mechanisms and evolutionary relationships at PSC using atomistic simulations and molecular phylogenetics. He was awarded a fellowship in 2001 to study at the Institute of Structural Biology in Grenoble, France, with Martin J
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CONNELL, Senior Scientist JESSICA DE MOUY, Research Associate CYNTHIA GETNER, Senior Financial Business Partner KANYA LONG, Senior Program Officer LYLY LUHACHACK, Associate Program Officer DASIA MCKOY, Program Assistant STEVEN MOSS, Senior Program Officer CHRISTL SAUNDERS, Program Assistant AUDREY THÉVENON, Senior Program Officer TRISHA TUCHOLSKI, Associate Program Officer SABINA VADNAIS, Research Associate HOANG-NAM VU, Program Assistant DAISHA WALSTON, Program Assistant 19
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RUCK, Merck Research Laboratories, Process Research & Development ANUP K SINGH, Lawrence Livermore National Laboratory VIJAY SWARUP, ExxonMobil Research and Engineering Company Staff BRENNA ALBIN, Program Assistant CHARLES FERGUSON, Senior Board Director MEGAN HARRIES, Program Officer AYANNA LYNCH, Program Assistant THANH NGUYEN, Financial Business Partner LINDA NHON, Program Officer NICHOLAS ROGERS, Senior Finance Business Partner LIANA VICCARI, Program Officer JESSICA WOLFMAN, Research Associate 20
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APPENDIX G ACKNOWLEDGMENT OF REPORT REVIEWER This Consensus Study Report was reviewed in draft form by an individual chosen for his technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published report as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the study charge.
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Recused IBN130013P Mindy Huang MCB100017P James Gumbart MCB100018P James Gumbart MCB110012P James Gumbart MCB150024P Xiaolin Cheng, Andrzej Kloczkowski MCB160089P Leonor Saiz MCB180091P Ravi Abrol MCB200076P Troy Wymore MCB210014P Leonor Saiz MCB220010P Denise Okafor 22
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