Sponsor Influences on the Quality and Independence of Health Research Proceedings of a Workshop (2023) / Chapter Skim
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2 Do Sponsoring Organizations Influence Research?
2 Do Sponsoring Organizations Influence Research?
Pages 3-10
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From page 3... ...
Research is a cyclical process that involves designing questions and methods, conducting research, and reporting the results, which generates further questions for additional research. If any of these steps fail, the value of the resulting evidence, synthesis, systematic reviews, and health and public health guidelines may be questionable.
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This analysis included 25 papers covering almost 3,000 studies and compared studies with drug industry sponsors with all of those with other sponsors, mostly government and nonprofit organizations. Industry-sponsored studies were about 30 times more likely than non-industry sponsored studies to report statistically significant efficacy estimates (Lundh et al., 2017)
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or that are part of human ethics research protocols and compares them to what is published. Another approach is to analyze internal industry documents released through legal settlements, which describe companies' scientific research and publication strategies.
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None of the much larger body of peer-reviewed research funded by the center focused on secondhand smoke; rather, it addressed subjects such as whether carpet off-gassing was harmful or having a plant in the office improved indoor air quality. These two examples, said Bero, "show how industry sponsors can drive a research agenda toward what we call ‘distracting research,' or research that distracts from harm of their product." Research Methods Bero then discussed whether the observed bias identified by metaresearch studies can be explained by differences in the methods used by industry and non-industry sponsors.
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Conduct of Research Bias can arise when investigators do not conduct their studies according to the research protocol. Internal pharmaceutical industry documents, said Bero, show that research and scientific publication are part of its marketing strategy, and the goal is to use research to disseminate information widely through the medical literature (Steinman et al., 2006)
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BREAKING THE CYCLE OF BIAS Bero provided a list of steps that could address the problem of sponsor-associated bias: • Publicly prioritizing research agendas and funding. • Recognizing industry funding and COIs as a source of bias and account for it.
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Unfortunately, she said, she has not seen a trend of decreasing industry sponsorship, despite changes in how industry money funnels into a university, which is something to watch. Session moderator Lonnie King, dean emeritus of the Ohio State University College of Veterinary Medicine, asked Bero if sponsors predetermine that they will have a say in the final publication.
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