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1 Introduction
Pages 1-4

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From page 1...
... This growing public health problem often includes a patient history of acute infection followed by long-lasting and often debilitating symptoms including severe fatigue, cognitive impairment, and multiorgan dysfunction. Lyle Petersen, director of the Division of Vector-Borne Diseases at the U.S.
From page 2...
... . In addition to the commonality in chronic symptoms among long COVID, PTLDS, ME/CFS, MS, and other illnesses, there are also similarities in the leading hypotheses for their mechanism of disease -- including pathogen or antigen persistence, immune response dysregulation, altered neurologic function, or altered microbiome composition and activity, among others.  Given this potential overlap, researchers studying different infection-associated chronic illnesses face common challenges in identifying disease biomarkers and developing diagnostics and therapeutic options. Recognizing the commonalities across the symptoms and research challenges, several speakers including Harlan Krumholz (Yale School of Medicine)
From page 3...
... The workshop sought to explore the current understanding of, and future research opportunities for, infection-associated chronic illnesses. Discussions were designed to consider the latest research and knowledge gaps in the following areas: • Overlapping clinical and biological factors underlying infection associated chronic illnesses • Current practice and novel technologies to develop urgently needed diagnostic tests for different stages of illness and the potential underlying infectious agent • Identification of therapeutic targets and strategies to prevent or impede chronic illness progression • Coordination and collaboration among various stakeholders and practitioners that will increase research and enhance care across different patient populations While some speakers and discussions presented in the workshop focused only on singular diseases, many aspects of the population profiles, symptomology, or biomarkers and therapeutic targets are likely salient across diseases and may apply to several different conditions.
From page 4...
... Finally, Chapter 7 considers challenges and opportunities in a shared research agenda. Suggestions for future research efforts and potential next steps by individual speakers are outlined in a box at the end of Chapter 7.


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