Research in Radiotherapy Approaches to Chemical Sensitization (1961) / Chapter Skim
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Pages 190-210
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KALLMAN: And we came in with the FUDR, 200 milligrams per kilogram, according to the same rationalization that Dr. Heidelberger mentioned.
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13. The Effect of Radiation upon Hair Growth in the Mouse, and Its Modification by Hypothyroidism and Actinomycin D Melvin L
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i Figure 13.1. A (left third)
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loo} 807 « . < =x 60+ / Y ‘ n a f o aol , / -- - -- HYPERTHYROD oa , se (t é -- -- NORMAL Pa weccccece D 20+ KHYPOTHYRO!
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RUBIN: What metabolic test did you do on the hyperthyroid animals to show they were hyperthyroid? GRIEM: We took groups of animals and put them in a typical BMR unit with a barium hydroxide absorber.
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regarding additive or synergistic effect in the patients because of the preliminary nature of this study. Before reporting the results in patients, however, I should like to show some data obtained in our laboratories to confirm the results that Dr.
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In another group were included patients with localized inoperable tumors which were considered relatively radioresistant. One such patient who was of some interest to us was a 57-year-old man who had an adenocarcinoma of the parotid and who had had a total of 14 operations since 1940 for recurrences.
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recurred following radiotherapy and radical surgery, and who had de- veloped metastatic disease in the neck nodes. After eight months the tumor recurred, was treated again, and regressed -- but only for a short time.
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time. There is no difference.
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metastases. Do you think you observed any difference between the two groups in the rate of regression, the number of cases with complete re- gression perhaps, or the number of cases in which some regression occurred?
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Regarding the specific question of whether we have seen any more regression in tumors that have been treated with combined therapy, the answer is that Idon't know. I would hesitate about making any definite statements because it is so difficult to be certain about it.
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In connection with this observation, I thought this morning, when Dr. Bagshaw showed the plates indicating that the tumor was growing under fluorouracil in some of the cultures, that this may perhaps have something to do with the stimulation of the tumor by the drug and that this stimulation to greater activity may make the tumor more radio- responsive.
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15. Clinical and Experimental Studies with Actinomycin D and Radiation G
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rather than the several months that is ordinarily required in our children. The next slide shows a rather surprising response to actinomycin, and one which is, I think, unique for the agent.
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Let me show you one example of rhabdomyosarcoma. This boy had a tumor primary in the orbital muscles.
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per kilogram. The animals were sacrificed at four, seven, and fourteen day intervals.
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the tumors never reappeared. There are four survivors of the original eight after 122 days.
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16. Clinical Results in the Treatment of Retinoblastoma with TEM and Radiation Norah duV.
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