Toxicants Occurring Naturally in Foods. (1966) / Chapter Skim
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Pages 211-231
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201 "(PS61) W I O X M O N ‘SHUG S u p "AZojoyIng ‘ABojojsdyg ‘KasspuayD ‘ s u u m ay]
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202 ROSEMARIE OSTWALD AND GEORGE M BRIGGS Biotin Biotin is nontoxic even in large amounts.
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VITAMINS 203 infant born to a mother who had received excess pyridoxine showed signs of "‘pyridoxine dependency," that is, an increase in pyridoxine requirement. A subsequent experiment with rats!
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204 ROSEMARIE OSTWALD AND GEORGE M BRIGGS It should also be remembered that large doses of one of the interrelated vitamins may precipitate deficiency symptoms of one of the others.
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VITAMINS 205 with riboflavin. It is interesting to note that, in mice, males tolerated dosages that were lethal to females.'®!
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206 ROSEMARIE OSTWALD AND GEORGE M BRIGGS other substances in capsule form is to be regretted.
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VITAMINS 207 Hypervitaminosis A has been observed in children given excess doses of high-potency vitamin A preparations as prophylactic measures and in adults taking excess doses in questionable attempts to cure certain skin diseases. Some cases of vitamin A poisoning have occurred in arctic explorers who had eaten large amounts of polar bear livers.
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208 ROSEMARIB OSTWALD AND GEORGE M BRIGGS but unpleasant, side effects.
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VITAMINS 219 Japanese workers have presented further evidence for the toxic effects of large amounts of vitamin A given to pregnant mice (10,000 IU by subcutaneous injection) on congenital defects of the developing embryos.® Case histories on vitamin A intoxication of children continue to be reported.'7 -- 9 Vitamin D The toxic effects of excess intake of vitamin D at the cellular level have been further investigated in experimental animals.
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