Toxicants Occurring Naturally in Foods. (1966) / Chapter Skim
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Pages 253-273
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From page 253... ...
GOSSYPOL 243 gossypol as the toxic substance in cottonseed. These and the subsequent publications by Schwartze and Alsberg,'4-!
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From page 254... ...
244 EDWARD EAGLE species that have yielded extensive physiologic information despite their limitations as sources of precise toxicologic data. But several in- vestigators had noted that a poor correlation existed between the gossypol content and the nutritional results obtained when cottonseed meals had been fed to rats and to chicks.*
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From page 255... ...
GOSSYPOL. 245 hemolysis,6!
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246 EDWARD EAGLE swine.22 But the processing procedures or treatments that cause these great reductions in gossypol content could hardly be so selective as to have no effect on any other factor(s) present.38 By selective breeding, geneticists have developed an almost glandless cottonseed, essentially free of gossypol.
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From page 261... ...
NITRATES AND NITRITES 251 namely, the large increase in nitrate content of some plants with high nitrogen fertilization and the reduction of nitrate to nitrite in vivo by bacterial action in the rumen.'3 Although most work on the problem has been done with cattle, the same type of acute effects have been seen in sheep,! ® although they appear less sensitive than cattle.
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From page 263... ...
NITRATES AND NITRITES 253 the increasing nitrate content associated with high nitrate fertilization might be hazardous to babies, especially if nitrate intake in some waters was considered. Gilbert et al.5 reported the high nitrate content of some vegetables but felt it was unlikely that any acute effects would result from normal intakes.
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From page 269... ...
OXALATES 259 oxalic acid. Furthermore, it is rather doubtful that oxalic acid exists in the free form in plants.32 The oxalates in vegetables such as spinach and rhubarb exists principally as the calcium or potassium salts.
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OXALATES 261 the possibility of influencing calcium metabolism. The role of oxalates was reviewed by Jeghers and Murphy!
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OXALATES 263 to this diet, some resorption of calcium from bones was noted and a negative balance occurred. However, if vitamin D was added to the diet, there was a large increase in uptake of calcium even in the presence of the sodium oxalate.
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