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Pages 274-294

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From page 275...
... OXALATES 265 combination of circumstances, a very high intake of oxalate-containing food plus a simultaneously low calcium and vitamin D intake over a prolonged period, for chronic toxic effects to be noted.
From page 277...
... GEORGE R MENEELY Toxic Effects of Dietary Sodium Chloride and the Protective Effect of Potassium Sodium chloride is naturally present in nearly all living things and, therefore, has always been a component of food.
From page 278...
... 268 GEORGE R MENEELY theory, attributed to von Bunge, that herbivorous animals are com- pelled to go to salt licks to obtain extra sodium chloride to balance the high intake of potassium characteristic of herbivorous diet.
From page 279...
... SODIUM CHLORIDE 269 while in canned peas drained of the liquor the potassium is reduced to 180 mg, and in frozen peas it is reduced to 160 mg. The fourth pathway is addition of salt in the cooking process within the home.
From page 280...
... 270 GEORGE R MENEBLY and some show no fall in blood pressure at all.
From page 281...
... SODIUM CHLORIDE 271 part in man in only a few parts of the world, most notably northern Japan. It was drastically hypertensigenic in the rat and it is drastically hypertensigenic in the Japanese.
From page 282...
... 272 GEORGE R MENEELY levels, while at lower levels of excess salt feeding the blood pressure rose less rapidly to intermediate hypertensive levels.
From page 283...
... SODIUM CHLORIDE 273 Each animal that died was autopsied, the organs were weighed and tissue sections obtained for microscopic examination. The weight of the kidneys and the weight of the heart increased in proportion to the sodium chloride in the diet and, of course, to the level of blood pressure which was also proportional to the salt in the diet.
From page 284...
... 274 GEORGE R MENBELY variation about this mean but, in most instances, not a sufficient spread among a sufficient number of individuals to reveal the hypertensigenic salt effect in the presence of other variables.
From page 285...
... SODIUM CHLORIDE 275 Throughout nature, potassium is the principal intracellular cation. It therefore is present in all foods.
From page 286...
... 276 GEORGE R MENEELY change in the hypertensigenic action of the extra sodium chloride, but there was a tremendous improvement in survival.
From page 287...
... SODIUM CHLORIDE 277 category were those rats with a highly excessive sodium chloride intake and an increased potassium intake. This group was characterized by the development of a moderate hypertension, a substantial prolongation of life when compared with animals eating the same amount of sodium chloride but without the supplemental potassium chloride, and a total body sodium that remained within normal limits.
From page 291...
... DISCUSSION 281 fruit, is irritating to the gastrointestinal tract. Lycopene, an aliphatic hydrocarbon related to carotene, accumulates in the liver and has caused illness in man as a result of the chronic consumption of large quantities of tomato juice.
From page 293...
... DISCUSSION 283 causes in the complex chemical context of the total diet. The relation- ships of goiter, lathyrism, favism, and ergotism with their specific dietary causes were slow in coming to light.

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