Biographical Memoirs Volume 64 (1994) / Chapter Skim
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Felix Haurowitz
Felix Haurowitz
Pages 134-163
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so much. Their impact will be enduring, and Felix Haurowitz was one of the great ones among them.
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His early education was at home with private teachers, then in a Catholic school run by a German order, and finally in a gymnasium. There for eight years he had Latin lessons daily and also studied Greek.
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as a volunteer assistant in the Department of Physiological Chemistry for Professor Richard von Zeynek, a hemoglobin chemist, ancI thereby began a life interest in this critical respiratory protein. His initial assignment was to work with Dr.
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War ~ in 1914. Haurowitz cleclined to write on pharmacology but wrote his first book, Biochemie des Menschen und der Tiere sell 1914.
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of patients with anemias failer! because there were no cases of thalassemia or sickle cell anemia in Prague.
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discuss with him what could be done to solve the mystery of antibody production. Thus began an exciting but short-lived collaboration that led to what was later callect the template theory of antibody formation.
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This ingenious procedure pioneered by Lanclsteiner was further developed by Felix Haurowitz who employed many different haptens and used it for quantitative determina · tion of the composition of the antigen-antibody precipitate, calculation of dissociation constants, anc! other parameters of the antibocly-antigen interaction.
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the Sucleten area of the country to Germany. The German University became an in(lepenclent university of the German Reich, and Haurow~tz was deprived of his right to teach.
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Alice registerer! as a student at Indiana University in Bloomington ant!
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In 1948 Indiana University was expanding rapidly anct was strong in chemistry and biology, particularly in genetics where it hac3 a famous group: H
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its persistence in phagocytic cells. For this study he used cliazotized aromatic amino acids labeled with radioactive isotopes 35S or ]
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international recognition came to Felix Haurowitz early in his scientific career, but major honors came rather late, perhaps because of the two mid-career moves resulting from the German invasion of Czechoslovakia. He was never active in professional societies though he did serve a term as chairman of the Division of Biological Chemistry of the American Chemical Society.
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A biographical memoir of Felix Haurowitz would be incomplete without a tribute to Gina Haurowitz, just as he would have been incomplete without her. Her death in Tune 1983 left him devastated.
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Also, I had many conversations with him over a period of thirty years, especially in the last two years of his life. Harry Day supplied much valuable biographical material, including the transcript of a 1978 interview with Felix Haurowitz on his life and work.
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FELIX HAUROWITZ ACADEMIC HISTORY AND HONORS DEGREES 1922 1923 HONORARY DEGREES 1973 1975 UNIVERSITY APPOINTMENTS M.D., German University of Prague D.Sc., German University of Prague M.D., University of Istanbul Ph.D., Indiana University 149 1920-25, Assistant; 1925-30, Docent; 1930-39, Assistant Professor, Department of Physiological Chemistry, Medical School of the German University, Prague 1939-48, Professor and Head, Department of Biological and Medical Chemistry, Medical School, University of Istanbul, Turkey 1948-58, Professor ofChemistry;195~66,Distinguished Professor, Department of Chemistry, Indiana University, Bloomington, Indiana MEMBERSHIPS 1960 1970 1975 Deutsche Akademie der Naturforscher Leopoldina American Academy of Arts and Sciences National Academy of Sciences AWARDS AND HONORARY MEMBERSHIPS 1960 1971 1972 1973 Paul Ehrlich Medal and Prize, Paul Ehrlich Foundation, Frankfurt, West Germany Award for Distinguished Services to Immunology, First International Congress of Immunology, Washington, D
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137:62-77. Zur Kenntnis des Methaemoglobins und seiner Derivate.
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Ueber die chemische Zusammensetzung der Qualle Velella spirans.
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Untersuchung des Praezipitates aus Haemoglobin und Anti-Haemoglobin-Serum und Bemerkungen ueber die Natur der Antikoerper Z Physiol.
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223:74-75. Konstitution und biologische Eigenschaften des Blutfarbstoffes und seiner Derivate.
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Marx. Loeslichkeit und Flockung der Proteine und anderer lyophiler Kolloide.
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95:478-86. Chemie der Antigene und der Antikoerper.
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47:309-13. Quantitative Untersuchungen ueber Antigen, Antikoerper und Komplement.
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The intracellular distribution in rabbit liver of injected antigens labeled with Ilk. Science 112:300-302.
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27:24780. 1953 Theories of antibody formation.
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Friedberg. The metabolic fate of injected homologous serum proteins in rabbits.
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Biosynthese der Proteine und ihre Beeinflussung durch Antigene. Naturwiss.
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1964 The template theory of antibody formation. In Conceptual Advances in Immunology and Oncology, pp.
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The evolution of selective and instructive theories of antibody formation. Cold Spring Harbor Symp.
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248:3810-18. The role of RNA in antibody formation.
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