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Environmental Medicine Integrating a Missing Element into Medical Education (1995) / Chapter Skim
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Case Study 10: Chronic Reactive Airway Disease Following Acute Chlorine Gas Exposure in an Asymptomatic Atopic Patient
Pages 289-290

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From page 289...
... Studies of soldiers gassed during the First World War showed evidence of obstructive airway disease and permanent disability.6" It is difficult to ascribe abnormalities found in these patients solely to chlonne inhalation for two reasons: chlonne was used only for a short time in chemical warfare, and most subjects studied were exposed to multiple war gases.' More recent series describe an initial obstructive defect, often with partial reversibility3 l3 l4; restrictive defects with accompanying diflilsion abnorrnalities have also been reported.' l4 These initial changes reverted to normal within a few months in almost all patients studied. In fact, in a study involving 820 patients, Jonest5 found no radiologic or clinical evidence of permanent pulmonary damage following industnal chloride exposure.
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From page 290...
... Charan et ala showed reversible acute airway `,bstr~cti<,n shortly after exposure and Hasan et alit reported the cases `,f tw`, asthmatic patients in whom chlorine gas may have exacerbated a state elf underlying hyperactivity. N<, fine however has reported new `'nset of severe reversible airway `,bstructi<'n that persisted several years after chlorine gas exposure.
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Key Terms

  • acute chlorine
  • chlorine exposure
  • gas exposure
  • following acute
  • pulmonary sequelae

  • pulmonary function
  • arch environ
  • hahnemann university
  • airway obstruction
  • chlorine inhalation

  • university hospital
  • environ health
  • airway disease
  • patients symptoms
  • gas inhalation

  • asthma following
  • found persistent
  • cigarette smoking
  • gas leak
  • prolonged expiration

  • chloride exposure
  • exposure resulting
  • aerosolized terbutaline
  • physical examination
  • acute pneumonitis

  • exacerbations necessitating
  • persistent obstructive
  • obstructive lung
  • cushingoid patient
  • severely debilitating


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