Environmental Medicine Integrating a Missing Element into Medical Education (1995) / Chapter Skim
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Case Study 43: Occupational Asthma Due to Toluene Diisocyanate Among Velcro-like Tape Manufacturers
Case Study 43: Occupational Asthma Due to Toluene Diisocyanate Among Velcro-like Tape Manufacturers
Pages 744-749
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From page 744... ...
Key words: TDI, asthma, isocyanates, MDI INTRODUCTION During September-November, 1985, four employees of a factory in Taipei County were seen in an outpatient clinic of the National Taiwan University Hospital complaining of cough, shortness of breath, chest tightness, and wheezing. The symptoms tended to be worse at night and improved after long holidays.
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found that the adhesive resin contained toluene diisocyanate (TDI) , a well-known cause of occupational asthma [NIOSH, 1978; Chan-Yeung and Lam, 1986; NIOSH, 1977b]
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We also recommended the factory change the formula of the adhesive resin and substitute diphenyl methane diisocyanate (MDI) for TDI, because MDI has a higher vaporization temperature and a lower vaporization pressure [ACGIH, 19803.
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The higher attack rates of asthmalike symptoms reported in our investigation may have been due to the difficulty in distinguishing true allergic cases from workers with other symptoms of pharmacologic reaction or pulmonary irritation, e.g., bronchitis, following exposure to high levels of TDI. We were able to show an objective reduction in pulmonary function for workers in areas with occasional high TDI concentrations.
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From page 748... ...
This investigation illustrates not only that occupational health problems exist in Taiwan, but they can often be remedied with minimal cost to industry. The key to improving occupational health among workers in Taiwan and elsewhere is to establish better procedures for licensing and inspecting factories and to train physicians and industrial hygienists to conduct proper health hazard evaluations and implement environmental control measures.
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: State of the art: Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis 112:335-65.
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