Biologic Markers in Urinary Toxicology (1995) / Chapter Skim
Currently Skimming:
7 CONCLUSIONS AND RECOMMENDATIONS
7 CONCLUSIONS AND RECOMMENDATIONS
Pages 217-226
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 217... ...
Current advances in epidemiology, biochemistry, molecular biology, and biologic-marl |
From page 218... ...
Conclusion Some susceptible populations in the 218 United States have anatomic or physiologic differences in the Ici(lneys at birth that Night help to explain their propensity for renal damage. As a result, they are less tolerant of various stresses, including exposure to environmental or occupational nephrotoxicants.
|
From page 219... ...
Recommendation Human blacicler cancer induced by xenobiotic exposure in worker cohorts should be investigated to develop strategies of individual risk assessment, to formulate programs for prevention, and to evaluate new forms of therapy. Strategies of indiviclual risk assessment need to be cleveloped as the cornerstone of prevention.
|
From page 220... ...
Recommendation Genetic and nongenetic factors that modify susceptibility to occupational and environmental genitouri nary toxicants and carcinogens should be considered in the evaluation of incliviclual susceptibility. These include sex, race, nutrition, socioeconomic factors, age, coexisting chronic disease, and drug abuse.
|
From page 221... ...
Recommendation A battery of relatively simple and noninvasive tests should be used as a first step in screening populations at rislc. On the basis of available information and technology, adequate initial screening results should be obtained by testing for proteinuria with dipsticks and then measuring urinary concentrating ability and serum creatinine and, for more sensitive measurements of tubular integrity, monitoring for an increase in urinary enzyme or low-molecularweight protein excretion.
|
From page 222... ...
Recommendation Several of the newer testing procedures hold promise of future usefulness and should be further investigated. Among them are tests of urinary excretion of various growth factors, such as epidermal growth factor (EGF)
|
From page 223... ...
Such studies have proved to be of considerable value and are necessary for a full appreciation of the effects of xenobiotics. Information gained from the study of environmental and occupational nephrotoxicants has been of fundamental value in identifying susceptible populations, reducing exposure, ally modifying effects.
|
From page 224... ...
Emphasis should also be placed on unclerstancling the mechanisms of cell growth, regeneration, and proliferation. Insight into the factors that control the cell cycle, regulate various growth factors, influence gene expression, and moclulate nucleic acid synthesis might be critical in the development of new classes of markers.
|
From page 225... ...
Recommendation Research on the relation of growth factors to the prostate requires rigorous experimental approaches and designs and must consider multiple variables. Studies of biochemical changes in the areas next to a prostatic tumor might be more informative than analysis of the cancer itself.
|
From page 226... ...
Assembly of those data into an organized framework will be a major step toward individual risk assessment and should be a longterm objective. Recommendation To achieve the desired goal of identifying more-useful mariners, cooperation between laboratory scientists, epidemiologists, and clinical re searchers should be encouraged.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.