Biographical Memoirs Volume 68 (1995) / Chapter Skim
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Irvine Heinly Page
Irvine Heinly Page
Pages 237-252
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From page 237... ...
, Hypertension Mechanisms, in 1987, Irvine Page was a dominant figure in the field of hypertension research. In a(ldition to his scientific contributions, which were many and seminal, his unflagging advocacy of hypertension as a major public health problem diet much to focus the attention of patients, physicians, investigators, ant!
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From page 238... ...
by Geheimrat Richarct Wilstatter to establish a department of brain chemistry at the Kaiser Wilhelm Institute of Psychiatry in Munich, Germany. Page in his memoir, Hypertension Research, recounts that in the three years he spent there his accomplishments were to set up a laboratory of neurochemistry and conduct research that gave "fats and sterols a better name." During that time he also accomplished a marriage to Beatrice Allen, a ciancer with the Denishawn Company.
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From page 239... ...
Prior to that observation, conventional wisdom held that elevated blood pressure was essential for blood to circulate through narrowed renal arteries. Toward the end of Page's stay at the Rockefeller Institute, Arthur Corcoran joined him, anti in 1937 the two men moved their research activity to the Laboratory for Clinical Research at the Inclianapolis City Hospital, which was supported in part by the Eli Lilly Company.
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From page 240... ...
Much was accomplished by him and his co-workers: serotonin was isolated and its pharmacology carefully detailed, the mosaic theory of hypertension was introduced and refined, the importance of the autonomic nervous system as the controlling mechanism in hypertension was firmly established, angiotensin was crystallized, treatment of hypertension was a constant and successful focus, the National Foundation for High Blood Pressure was begun, and the Institute of Medicine had its origins there. Retirement for Irvine Page did not mean a retirement from hypertension activities; he only changed his venue by moving to Hyannis Port.
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From page 241... ...
The honor of election to the National Academy of Sciences came to Page in 1971, some time after his major scientific contributions. Having known him as T clid through an association of forty-three years ~ can hear him say "about time." Of course, he was immensely pleased but being a bit of a curmudgeon was a necessary part of his public persona.
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From page 242... ...
Oscar Helmer prepared protein fractions of kidneys, which were tested for their ability to raise blooc! pressure in the clog by Page; to cause vasoconstriction in isolated vascular beds by KohIstaecit; anti to decrease blooc!
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From page 243... ...
The renin-angiotensin system is widely distributed and has been identified in blood vessels, brain, salivary glands, uterus, placenta, adrenal, and, of course, the kidney, where it was originally found. It is one of the most important systems of the body: it regulates blood pressure by directly affecting the smooth muscle of arteries, it is the primary factor in aldosterone release, it has an independent effect on salt excretion by the kidney, and it influences brain function.
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From page 244... ...
by bloocl pressure control. From 1951, when antihypertensive drugs of Tongterm effectiveness were first introclucecI, until his retirement in 1966, Page was actively concerned!
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From page 245... ...
In the early 1960s Page became convincer! that establishment of a National Academy of Medicine would benefit by bridging "the wide gaps among government, the American Medical Association, specialty societies, academia and inclustry an ecumenical movement." He used his Modern Medicine editorials to test the waters.
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From page 246... ...
medicine in the United States. MATERIALS USED IN WRITING this memoir came from my forty-threeyear friendship with Irvine Page, twenty-four years of which I worked closely with him; from his book Hypertension Research, A Memoir, 1920-1960, and from a rereading of his major scientific papers.
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From page 247... ...
Gould Memorial Award of the American Association for the Advancement of Science ~ 1957~; Albert Lasker Award ~ 1958~; Gairdner Foundation Award (1963~; Distinguished Award of the American Medical Association (1964~; Oscar B Hunter Award (1966~; Passano Foundation Award (1967~; and the Stouffer Prize for Hypertension Research (1970~.
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From page 248... ...
A crystalline presser substance (angiotonin) resulting from the reaction between renin and renin activator.
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From page 249... ...
Arterial pressure responses to discontinuing antihypertensive drugs. Circulation 37:370-79.
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From page 250... ...
1988 Hypertension Research, A Memoir, 1920-1960. New York: Pergamon Press.
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