Biographical Memoirs Volume 68 (1995) / Chapter Skim
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Min Chueh Chang
Min Chueh Chang
Pages 45-62
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From page 45... ...
~ 991 BY ROY O GREEP THE LIFE WORK OF Min Chueh Chang centered on a discrete portion of the mammalian reproduction process, the part that begins with the existence of male ant!
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From page 46... ...
His life career is a story of triumph and disappointments, perseverance and major accomplishments, accolades, international recognition, and, lastly, an element of what Peter Meciawar recognized as chance. It was largely by chance that Chang often found himself the right man at the right place at the right time.
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Over the next few years of turbulent times in China, Chang stayed at the university as a teacher and made some original observations on the staining of nerve cells that gained publication in a prestigious American journal. Chang's brilliance of mind and unbounded!
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clinical research on reproduction. In Chang's laboratory they were mainly left to their own crevices except that Chang was always at hand for helpful guidance ant!
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Their three chiTciren inclucle two daughters, Claudia Chang Tourtellotte, head of the anthropology department at Sweet Briar College in Sweet Briar, Virginia; Pamela O'Malley Chang, an architect and civil engineer in San Francisco, California; and a son, Francis Hugh Chang, director of a health center in Boston, Massachusetts.
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his son and mate dominance of the marital relationship. Much credit must be given to Chang's talented wife for her willing acquiescence in the role of a Confucian wife as her part in enabling Chang to develop his full potential unhindered by domestic concerns.
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In his initial studies on eggs and sperm Chang carried out a variety of experiments mainly to acquire expertise in the techniques involved and to gain a thorough knowledge of the field. He examined the motility and fertilizing capacity of sperm taken from different areas of the mate reproductive tract, with special attention to sperm from various parts of the epididymis.
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From page 52... ...
by the female gonads. He found that of approximately 200 million sperm cleposited in the rabbit vagina by ejaculation or artificial insemination barely ~ percent make it past the cervical barrier to the uterine cavity and only about 5,000 find their way past the utero-tubal junction.
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From page 53... ...
Sperm deposited in the rabbit vagina on mating reach the fallopian tubes within minutes and await the arrival of ova for fertilization ten to twelve hours later. In a fateful experiment Chang deposited ejaculated sperm in the tubes to coincide with the arrival of ova.
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From page 54... ...
Taking this one step further, they found that clecapacitatec3 sperm could be recapacitated by placing them back in the uterus or tubes. In a 1958 study of the possible influence of the hormonal status of the female rabbit reproductive tract on the capacitation of sperm, Chang found that ejaculated sperm placed in the uteri of pseuclopregnant or progesterone-treated rabbits failecl to become capacitated.
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Chang's crowning achievement came in 1959 with his demonstration that eggs from a black rabbit fertilized in vitro by capacitated sperm from a black male ant! transferred to a white female resulted in the birth of a litter of black young.
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From this overview of the entire spectrum of Chang's Investigational program, it is evident that the central and constant objective was understanding the detailed circumstances involved in the process of sperm penetration and fertilization of mammalian ova. Such was the fabric of his illustrious career.
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It was an elegant appeal to await full understanding of what happens to sperm during that still ever so puzzling waiting period. PERSONAL COMMENTS BY THE AUTHOR Chang was an easily recognized figure, tall and slimly built with a copious head of dark hair tinged with gray.
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Such tenacity has become a rarity in biomedical research clue to the tenuousness of financial support. Chang's rise to prominence as a Chinese scholar (luring a perioc!
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:118-19. 1951 Fertilizing capacity of sperm deposited in the fallopian tube.
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Hunt. Effects of in vitro radiocobalt irradiation of rabbit ova on subsequent development in viva with special reference to the irradiation of maternal organism.
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Fertilization of rat eggs in vitro by epididymal spermatozoa and the development of eggs following transfer.
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